Nimodipine

Nimodipine is a prescription medication used for the treatment of subarachnoid hemorrhage.

• Temozolomide is available under the following different brand names: Nimotop, Nymalize

Adult dosage

Gel capsule

• 30 mg

Oral solution (Nymalize)

• 30 mg/10 mL(DSC)
• 60mg/20 mL(DSC)
• 6mg/mL

Subarachnoid Hemorrhage

Adult dosage

• 60 mg orally every 4hrs for 21 days; begin therapy within 96 hours of subarachnoid hemorrhage

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

Common side effects of Nimodipine include:

• low blood pressure (feeling light-headed),
• nausea,
• upset stomach,
• slow heartbeats, and
• muscle pain

Serious side effects of Nimodipine include:

• hives,
• difficulty breathing,
• swelling of the face, lips, tongue, or throat,
• lightheadedness,
• fast or slow heart rate, and
• swelling of the ankles or feet

Rare side effects of Nimodipine include:

• none 

This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Nimodipine has severe interactions with no other drugs.
• Nimodipine has serious interactions with at least 17 drugs
• Nimodipine has moderate interactions with at least 57 other drugs
• Nimodipine has minor interaction with at least 57 other drugs. 

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns.

Contraindications

• Hypersensitivity
• Parenteral administration; risk of death

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Nimodipine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Nimodipine?”

Cautions

• Blood pressure should be carefully monitored during treatment based on its known pharmacology and the known effects of calcium channel blockers
• Reflex tachycardia may occur, which may result in angina and/or myocardial infarction in patients with obstructive coronary disease, particularly if not being treated with beta-blockers
• Peripheral edema may occur within 2-3 weeks of starting therapy
• Metabolism decreased in patients with hepatic impairment; such patients should have their blood pressure and pulse rate monitored closely and should be given a lower dose
• Use caution in hepatic impairment or hypertrophic subaortic stenosis
• Hypotension with or without syncope is possible (particularly with severe aortic stenosis)
• Intestinal pseudo-obstruction and ileus reported rarely; a causal relationship not established; the condition has responded to conservative management
• A decreased dose may be required with strong CYP3A4 inhibitors

Pregnancy and Lactation

• Use with caution if benefits outweigh risks during pregnancy
• Lactation: unknown; avoid