How Do NMDA Antagonists Work?

NMDA (N-methyl-D-aspartate) receptor antagonists are a class of drugs that may treat memory loss and brain damage associated with Alzheimer’s disease.

NMDA receptor allows the binding of the excitatory neurotransmitter glutamate to its site. When glutamate attaches to the NMDA receptor, it releases calcium into the nerve cells that is essential for the learning process and memory.

When the glutamate level increases in the brain, it causes excess release of calcium, which can damage the nerve cells.

NMDA antagonists bind to NMDA receptors and prevent the binding of glutamate, thereby preventing the release of calcium into the nerve cells.

NMDA antagonists are prescribed to treat the following conditions:

• Alzheimer’s disease
• Pseudobulbar affect
• Major depressive disorder
• Alzheimer-type dementia

NMDA antagonists can cause the following side effects:

• Dizziness
• Confusion
• Headache
• Constipation
• Cough
• Hypertension
• Backache
• Pain
• Somnolence (daytime sleepiness)
• Syncope (blackout)
• Vomiting
• Dyspnea (shortness of breath)
• Fatigue

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of NMDA antagonists include:

• Dextromethorphan/quinidine
• Esketamine intranasal
• Memantine
• Memantine/donepezil
• Namenda
• Namenda XR
• Namzaric
• Nuedexta
• Spravato