Paromomycin

Paromomycin is a prescription medication used for the treatment of parasitic infections.

• Paromomycin is available under the following different brand names: Humatin

Adult and pediatric dosage

Capsule

• 250mg

Intestinal Amebiasis (E. Histolytica)

Adult dosage

• 25-35 mg/kg/day orally divided every 6 hours for 5-10 days 

Pediatric dosage

• 25-35 mg/kg/day orally divided every 8 hours for 5-10 days

Hepatic Coma (Adjunctive)

Adult dosage

• 4 g orally every day in divided doses for 5-6 days

Diantomoeba Fragilis

Adult dosage

• 20-30 mg/kg/day orally divided every 8 hours

Pediatric dosage

• 25-30 mg/kg/day orally divided every 8 hours for 7 days 

Tapeworm (T. saginata/T. solium/D. latum/D. caninum)

Adult dosage

• 11 mg/kg orally divided every 15 mins for 4 doses

Pediatric dosage

• 11 mg/kg orally divided every 15 mins for 4 doses

Dwarf Tapeworm

Adult dosage

• 45 mg/kg/dose orally once daily for 5-7 days

Pediatric dosage

• 45 mg/kg/dose orally once daily for 5-7 days

E. Histolytica

Pediatric dosage

• 25-35 mg/kg/day divided every 8 hours orally for 7 days OR
• 750 mg/m²/day divided every 6 hours orally for 5 days

Tapeworm (Hymenolepis nana)

Pediatric dosage

• 45 mg/kg orally once daily  for 5-7 days

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

Common side effects of Paromomycin include:

• nausea,
• stomach cramps; or
• mild diarrhea.

Serious side effects of Paromomycin include:

• hives,
• difficult breathing,
• swelling of the face, lips, tongue, or throat,
• watery or bloody diarrhea; or
• worsening symptoms

Rare side effects of Paromomycin include:

• none 

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Paromomycin has severe interactions with no other drugs.
• Paromomycin has serious interactions with the following drugs:
  • atracurium
  • axicabtagene ciloleucel
  • BCG vaccine live
  • brexucabtagene autoleucel
  • bumetanide
  • ciltacabtagene autoleucel
  • cisatracurium
  • ethacrynic acid
  • furosemide
  • idecabtagene vicleucel
  • lisocabtagene maraleucel
  • onabotulinumtoxinA
  • pancuronium
  • quinidine
  • rapacuronium
  • rocuronium
  • succinylcholine
  • tisagenlecleucel
  • torsemide
  • typhoid vaccine live
  • vecuronium
• Paromomycin has moderate interactions with at least 52 other drugs.
• Paromomycin has minor interactions with at least 76 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns.

Contraindications

• Hypersensitivity, intestinal obstructions

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Paromomycin?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Paromomycin?”

Cautions

• Prolonged treatment may result in fungal or bacterial superinfection
• Caution in renal impairment or patients with ulcerative bowel lesions

Pregnancy and Lactation

• Use with caution if benefits outweigh risks during pregnancy

Lactation

• Does not enter breast milk