Pegloticase

Pegloticase is a prescription medication used for treating gout. 

• Pegloticase is available under various brand names: Krystexxa

Common side effects of Pegloticase include:

• allergic reactions;
• new gout flares;
• vomiting, constipation;
• bruising; or
• sore throat.

Serious side effects of Pegloticase include:

• hives,
• difficult breathing,
• swelling of the face, lips, tongue, or throat
• severe stomach pain, diarrhea that is watery or bloody;
• nervous, 
• light-headed,
• itchy, 
• short of breath, 
• fast heartbeats, 
• chest discomfort, or 
• redness of the skin during the injection
• chest pain; or
• flushing (warmth, redness, or tingly feeling).

Rare side effects of Pegloticase include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Injectable solution

• 8 mg/mL

Gout

Adult dosage

• 8 mg IV infusion every 2 weeks coadministered with methotrexate 15 mg orally every week

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Pegloticase has severe interactions with no other drugs.
• Pegloticase has serious interactions with no other drugs.
• Pegloticase has moderate interactions with the following drugs:
  • certolizumab pegol
  • pegademase
  • pegaptanib
  • pegaspargase
  • pegfilgrastim
  • peginterferon alfa 2a
  • peginterferon alfa 2b
  • pegvaliase
  • pegvisomant
  • siponimod
• Pegloticase has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• allergic to pegloticase
• glucose-6-phosphate dehydrogenase (G6PD) deficiency

Effects of drug abuse

• none.

Short-Term Effects

• See “What Are Side Effects Associated with Using Pegloticase?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Pegloticase?”

Cautions

• You should not receive Pegloticase if you are allergic to it or have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
• Tell your caregivers immediately if you feel itchy, light-headed, short of breath, or have chest discomfort or skin redness during the injection.

Pregnancy and Lactation

• It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Lactation

• It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.