Pentazocine-Naloxone

Pentazocine-Naloxone is a combination medication used to relieve moderate-to-severe pain. 

• Pentazocine-Naloxone is available under the following different brand names: Talwin NX 

Common side effects of Pentazocine-Naloxone include:

• Dizziness,
• Drowsiness,
• Mild constipation,
• Nausea,
• Vomiting, and
• Sweating

Serious side effects of Pentazocine-Naloxone include:

• Hives,
• Difficulty breathing,
• Swelling of the face, lips, tongue, or throat,
• Severe skin reaction,
• Fever,
• Sore throat,
• Burning in the eyes,
• Skin pain,
• Red or purple skin rash that spreads and causes blistering and peeling,
• Slow breathing with long pauses,
• Blue-colored lips,
• Hard to wake up,
• Slow heartbeats,
• Weak or shallow breathing,
• Severe constipation,
• Confusion,
• Hallucinations,
• Unusual thoughts or behavior,
• Severe weakness,
• Drowsiness.
• Seizure,
• Lightheadedness,
• Nausea,
• Vomiting,
• Loss of appetite,
• Dizziness,
• Worsening tiredness or weakness,
• Agitation,
• Hallucinations,
• Unusual thoughts or behavior,
• Sweating,
• Shivering,
• Fast heart rate,
• Muscle stiffness,
• Twitching,  
• Loss of coordination, and
• Diarrhea

Rare side effects of Pentazocine-Naloxone include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Tablet: Schedule IV

• 50 mg/0.5 mg

Moderate-to-Severe Pain

Adult and geriatric dosage

• 1 tablet orally every 3-4 hours, may increase to 2 tablets every 3-4 hours or as needed; not to exceed 12 tablets/day

Pediatric dosage

• Children below 12 years: Safety and efficacy not established
• Children above 12 years: As adults; tablet orally every 3-4 hours, may increase to 2 tablets every 3-4 hours or as needed; not to exceed 12 tablets/day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Pentazocine-Naloxone has severe interactions with the following drug:
  • Alvimopan
• Pentazocine-Naloxone has serious interactions with at least 52 other drugs.
• Pentazocine-Naloxone has moderate interactions with at least 222 other drugs.
• Pentazocine-Naloxone has minor interactions with the following drugs:
  • Aspirin
  • Aspirin rectal
  • Aspirin/citric acid/sodium bicarbonate
  • Brimonidine
  • Dextroamphetamine
  • Eucalyptus
  • Lidocaine
  • Sage
  • Ziconotide

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity
• Do not inject dissolved tablets
• If prescribed for long-term use, take precautions to avoid increases in dose by the patient

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Pentazocine-Naloxone?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Pentazocine-Naloxone?”

Cautions

• None

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy.
• Lactation
  • Use caution