Pneumococcal Vaccine 21-Valent

Pneumococcal Vaccine 21-Valent is a vaccine indicated in individuals 18 years of age and older for active immunization for prevention of:

• Invasive disease caused by Streptococcus pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15B, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F, and 35B
• Pneumonia caused by S pneumoniae serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F, and 35B

Pneumococcal Vaccine 21-Valent is available under the following different brand names: Capvaxive.

Common side effects of Pneumococcal Vaccine 21-Valent include:

• pain, redness, or swelling at the injection site
• feeling tired
• headache
• muscle aches
• fever

Serious side effects of Pneumococcal Vaccine 21-Valent include:

• wheezing or trouble breathing
• swelling of the face, lips, or tongue
• hives
• rash

Rare side effects of Pneumococcal Vaccine 21-Valent include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Injection, solution for IM

• 0.5 mL/single-dose prefilled syringe

Streptococcus pneumoniae immunization

Adult dosage

• 0.5 mL IM once, as a single dose

Vaccination schedules are available at https://www.cdc.gov/vaccines/

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Pneumococcal Vaccine 21-Valent has no noted severe interactions with any other drugs
• Pneumococcal Vaccine 21-Valent has no noted serious interactions with any other drugs
• Pneumococcal Vaccine 21-Valent has no noted moderate interactions with any other drugs
• Pneumococcal Vaccine 21-Valent has no noted minor interactions with any other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• History of a severe allergic reaction (eg, anaphylaxis) to any component of the vaccine or diphtheria toxoid

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Pneumococcal Vaccine 21-Valent?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Pneumococcal Vaccine 21-Valent?”

Cautions

• Appropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration
• Individuals with altered immunocompetence, including those receiving immunosuppressive therapy, may have a reduced immune response

Pregnancy and Lactation

• There are no adequate and well-controlled studies in pregnant women
• Lactation
  • Human data are not available to assess the impact on milk production, the presence in breast milk, or its effects on breastfed children
  • Consider the developmental and health benefits of breastfeeding with the mother’s clinical need for immunization and any potential adverse effects on the breastfed child from the vaccine or underlying maternal condition
  • For preventive vaccines, the underlying condition is susceptibility to disease prevented by the vaccine