Potassium Phosphate/Sodium Acid Phosphate

Potassium phosphate/sodium acid phosphate is used low blood phosphate levels (hypophosphatemia) and low urinary phosphate.

Potassium phosphate/sodium acid phosphate is available under the following different brand names: K-Phos M.F., K-Phos No. 2, K-Phos Neutral, Neutra-Phos, and Uro-KP Neutral.

Dosages of Potassium Phosphate/Sodium Acid Phosphate:

Dosage Forms and Strengths

Tablet

• 126mg/67mg
• 250mg/298mg
• 250mg/160mg

Dosage Considerations – Should be Given as Follows:

Hypophosphatemia

• Adults: K-Phos Neutral: 1-2 tablets orally every 4 hours
• Children 4 years and older: K-Phos Neutral, 1 tablet orally every 6 hours;
• Adults: Phos-NaK: 1 packet mixed with 75 mL water or juice
• Children 4 years and older: Phos-NaK, 1 packet orally every 6 hours mixed with 75 mL water or juice
• Children under 4 years: Safety and efficacy not established

Low Urinary Phosphate

• Adults and children 4 years and older: 1-2 tablets orally every 6 hours
• Children under 4 years: Safety and efficacy not established

Dosage Modifications

• Renal impairment: Use with caution in patients with chronic renal disease or renal function impairment

Side effects of potassium phosphate/sodium acid phosphate include:

• Confusion
• Dizziness
• Fast heart rate
• Gastrointestinal (GI) upset
• Headache
• Low urine output
• Lower-extremity swelling
• Mild laxative effect
• Numbness or tingling
• Shortness of breath
• Thirst
• Weakness or heaviness of legs
• Weight gain

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Severe interactions of potassium phosphate/sodium acid phosphate include:
  • sodium phosphate rectal
• Serious interactions of potassium phosphate/sodium acid phosphate include:
  • baloxavir marboxil
  • erdafitinib
  • potassium phosphates, IV
• Moderate interactions of potassium phosphate/sodium acid phosphate include:
  • deflazacort
  • dextroamphetamine
  • lisdexamfetamine
  • magnesium supplement
  • methamphetamine
  • methylenedioxymethamphetamine
  • omadacycline
  • potassium iodide
  • sarecycline
• Potassium phosphate/sodium acid phosphate has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

• This medication contains potassium phosphate/sodium acid phosphate. Do not take K-Phos M.F., K-Phos No. 2, K-Phos Neutral, Neutra-Phos, or Uro-KP Neutral if you are allergic to potassium phosphate/sodium acid phosphate or any ingredients contained in this drug.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Patients with infected phosphate stones
• Severe renal impairment
• High blood phosphates (hyperphosphatemia)
• Addison disease
• High blood potassium (hyperkalemia)
• Infected urolithiasis
• Struvite stone formation

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Potassium Phosphate/Sodium Acid Phosphate?”

Long-Term Effects

• See "What Are Side Effects Associated with Using Potassium Phosphate/Sodium Acid Phosphate?”

Cautions

• Use caution in cardiac disease, especially in digitalized patients, adrenal insufficiency, acute dehydration, renal disease, extensive tissue breakdown, as in severe burns, myotonia congenita, cirrhosis of the liver, edema, hypertension, hypoparathyroidism, acute pancreatitis, hepatic impairment, hypernatremia, metabolic alkalosis

Pregnancy and Lactation

• Use potassium phosphate/sodium acid phosphate with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
• It is unknown if potassium phosphate/sodium acid phosphate is distributed in breast milk. Caution is advised while breastfeeding.