How Do Pyrimidine Synthesis Inhibitors Work?

Pyrimidine synthesis inhibitors are drugs used for the treatment of multiple sclerosis. 

Multiple sclerosis is an autoimmune disease where the immune system attacks the central nervous system. The production of pyrimidine is responsible for the activation and multiplication of white blood cells (lymphocytes). Multiplication of lymphocytes leads to the inflammatory response associated with multiple sclerosis.

Pyrimidine synthesis inhibitors inhibit the action of an enzyme called dihydro-orotate dehydrogenase, responsible for pyrimidine production. Thus, they are responsible for blocking lymphocyte activation and inflammatory response.

Pyrimidine synthesis inhibitors are mainly used for treating multiple sclerosis.

The most common side effects of pyrimidine synthesis inhibitors include:

• Headache
• Diarrhea
• Hair loss
• Nausea
• Upper respiratory tract infection
• Toothache
• Blurred vision
• Anxiety
• Itching
• Hypertension
• Oral herpes
• Viral gastroenteritis
• Seasonal allergy
• Burning sensation
• Palpitations
• Decreased weight
• Acne

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of pyrimidine synthesis inhibitors include:

• Aubagio
• Teriflunomide