Rifampin-Isoniazid

Rifampin-Isoniazid is a combination medication used to treat the symptoms of Tuberculosis.

• Rifampin-Isoniazid is available under the following different brand names: Rifamate (Discontinued)

Common side effects of Rifampin-Isoniazid include:

• Red-orange coloration of tears, sweat, saliva, urine, or stools,
• Numbness,
• Tingling,
• Itching,
• Mild rash,
• Drowsiness,
• Dizziness,
• Headache,
• Muscle pain or weakness,
• Heartburn,
• Gas,
• Diarrhea, and
• Mouth pain

Serious side effects of Rifampin-Isoniazid include:

• Hives,
• Difficulty breathing,
• Swelling of the face, lips, tongue, or throat,
• Nausea,
• Upper stomach pain,
• Weakness,
• Tiredness,
• Loss of appetite,
• Dark urine,
• Clay-colored stools,
• Yellowing of the skin or eyes (jaundice),
• Vision changes,
• Confusion,
• Hallucinations,
• Unusual thoughts or behavior,
• Fever,
• Unusual weakness,
• Pale skin,
• Easy bruising,
• Unusual bleeding (nose, mouth, vagina, or rectum), and
• Purple or red pinpoint spots under your skin

Rare side effects of Rifampin-Isoniazid include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage (Product discontinued)

Capsule

• 300 mg/150 mg

Tuberculosis

Adult dosage

• Rifampin 600 mg-Isoniazid 300 mg (.e, 2 capsules) orally once a day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Rifampin-Isoniazid has severe interactions with at least 55 other drugs.
• Rifampin-Isoniazid has serious interactions with at least 274 other drugs.
• Rifampin-Isoniazid has moderate interactions with at least 452 other drugs.
• Rifampin-Isoniazid has minor interactions with at least 133 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to isoniazid, rifamycins
• Acute liver disease, severe hepatic damage, acute gout
• Rifampin is contraindicated in patients receiving ritonavir-boosted saquinavir due to an increased risk of severe hepatocellular toxicity
• Rifampin is contraindicated with many drugs that are substrates of CYP, particularly CYP3A4
• Rifampin coadministration in patients receiving atazanavir, darunavir, fosamprenavir, saquinavir, or tipranavir may substantially decrease plasma concentrations which may result in loss of antiviral efficacy for HIV infection and/or development of viral resistance

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Rifampin-Isoniazid?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Rifampin-Isoniazid?”

Cautions

• History of diabetes mellitus (may make diabetes management more difficult)
• Rifampin is not recommended for intermittent therapy; caution patient against intentional or accidental interruption of daily dosage regimen since rare renal hypersensitivity reactions have been reported when therapy was resumed in such cases
• Rifampin has enzyme induction properties that can enhance the metabolism of endogenous substrates including adrenal hormones, thyroid hormones, and vitamin D

Pregnancy and Lactation

• No adequate and well-controlled studies have been performed in pregnant women; is teratogenic in rodents
• Rifampin has been reported to cross the placental barrier and appear in cord blood
• When administered during the last few weeks of pregnancy, rifampin can cause postnatal hemorrhages in the mother and infant for which treatment with vitamin K may be indicated
• Use during pregnancy only if the potential benefit justifies the potential risk to the fetus

Lactation

• Because of the potential for tumorigenicity shown for rifampin in animal studies, a decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.