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Risperdal vs. Seroquel for Treatment of Schizophrenia: Differences & Side Effects

Risperdal vs. Seroquel

Are Risperdal and Seroquel the Same Thing?

Risperdal (risperidone) and Seroquel (quetiapine) are antipsychotic drugs prescribed to treat schizophrenia.

Risperdal is also used to treat bipolar mania and autism.

Seroquel is also used to treat major depression and bipolar disorder.

What Are Possible Side Effects of Risperdal?

Common side effects of Risperdal include:

  • extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes),
  • dizziness,
  • tiredness,
  • drowsiness,
  • fatigue,
  • fever,
  • weight gain,
  • feeling hot or cold,
  • headache,
  • dry mouth,
  • increased appetite,
  • restlessness,
  • anxiety,
  • sleep problems (insomnia),
  • nausea,
  • vomiting,
  • stomach pain,
  • constipation,
  • cough,
  • sore throat,
  • runny or stuffy nose,
  • or skin rash.

Tell your doctor if you experience serious side effects of Risperdal including difficulty swallowing, muscle spasms, shaking (tremor), mental/mood changes, or signs of infection (such as fever, persistent sore throat).

What Are Possible Side Effects of Seroquel?

Common side effects of Seroquel include:

  • fever,
  • hot flashes,
  • sensitivity to heat,
  • sweating,
  • headache,
  • nervousness,
  • irritability,
  • nausea,
  • sleep problems (insomnia),
  • changes in appetite or changes in weight,
  • changes in menstrual perdiods,
  • and temporary hair loss.

What is Risperdal?

Risperdal (risperidone) is an atypical antipsychotic prescribed to treat:

  • schizophrenia,
  • bipolar mania,
  • and autism.

What is Seroquel?

Seroquel is a prescription medicine used to treat:

  • schizophrenia in people 13 years of age or older
  • bipolar disorder in adults, including:
    • depressive episodes associated with bipolar disorder
    • manic episodes associated with bipolar I disorder alone or with lithium or divalproex
    • long-term treatment of bipolar I disorder with lithium or divalproex
  • manic episodes associated with bipolar I disorder in children ages 10 to 17 years old

It is not known if Seroquel is safe and effective in children under 10 years of age.

What Drugs Interact With Risperdal?

Risperdal may interact with other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), carbamazepine, fluoxetine, paroxetine, phenytoin, phenobarbital, or rifampin.

Risperdal may also interact with cimetidine, ranitidine, clozapine, valproic acid, or medicines used to treat Parkinson's Disease.

What Drugs Interact With Seroquel?

Seroquel may interact with seizure medications.

Seroquel may also interact with other medicines that make you sleepy (cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), medications to treat high blood pressure or a heart condition, medications to treat Parkinson's disease, steroids, antibiotics, antifungals, anti-malaria medications, heart rhythm medicines, medications to treat HIV or AIDS, migraine headache medicines, or other antidepressant or medicines to treat psychiatric disorders.

How Should Risperdal Be Taken?

Risperdal dose ranges from 0.5 mg to 8mg/day.

How Should Seroquel Be Taken?

Dosing preparations are 25, 50, 100, 200, 300, and 400 mg tablets.

  • Take Seroquel exactly as your healthcare provider tells you to take it. Do not change the dose yourself.
  • Take Seroquel by mouth, with or without food.
  • If you feel you need to stop SEROQUEL, talk with your healthcare provider first. If you suddenly stop taking SEROQUEL, you may have side effects such as trouble sleeping or trouble staying asleep (insomnia), nausea, and vomiting.
  • If you miss a dose of SEROQUEL, take it as soon as you remember. If you are close to your next dose, skip the missed dose. Just take the next dose at your regular time. Do not take 2 doses at the same time unless your healthcare provider tells you to. If you are not sure about your dosing, call your healthcare provider.
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

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If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

FDA. Risperdal Drug Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020272s056,020588s044,021346s033,021444s03lbl.pdf
FDA. Seroquel Drug Information.
https://www.seroquelxr.com/