RiVive

What Is RiVive?

RiVive (naloxone hydrochloride spray) is an over-the-counter opiate antagonist used for emergency treatment of opioid overdose to “revive” someone during an overdose from many prescription pain medications or street drugs such as heroin. This medicine can save a life.

What Are Side Effects of RiVive?

Side effects of RiVive are expected when a person wakes up, including:

• shaking,
• sweating,
• nausea, and
• feeling angry.

Seek medical care or call 911 at once if you have the following serious side effects:

• Serious eye symptoms such as sudden vision loss, blurred vision,tunnel vision,eye painor swelling, or seeing halos around lights;
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
• Severe headache,confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for RiVive

Each spray contains only one dose of naloxone 3 mg. If an overdose is suspected, administer the 1st dose of RiVive nasal spray into the nose and call 911. Watch and wait.

If the person does not wake up in 2-3 minutes after the first dose, give a second dose. It is safe to keep giving doses every 2-3 minutes until the person wakes up or emergency personnel arrive.

RiVive In Children

The recommended initial dose of RiVive Nasal Spray in adults and pediatric patients is one spray delivered by intranasal administration into one nostril.

What Drugs, Substances, or Supplements Interact with RiVive?

RiVive may interact with other medicines.

Tell your doctor all medications and supplements you use.

RiVive During Pregnancy and Breastfeeding

Although induced withdrawal may possibly contribute to fetal stress, RiVive Nasal Spray should be used in pregnant people in the case of maternal overdose in order to save the mother’s life. Use of RiVive may cause withdrawal symptoms in an unborn baby. The baby should be examined by a healthcare provider right away after use of RiVive Nasal Spray. Breastfeeding should be encouraged in those who are stable on their opioid agonists, who are not using illicit drugs, and who have no other contraindications, such as human immunodeficiency virus (HIV) infection. Consult your doctor before breastfeeding.

Additional Information

Our RiVive (naloxone hydrochloride spray) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.