Same

Same is a molecule formed naturally in the body and used in various conditions such as depression, osteoarthritis, intrahepatic cholestasis alcohol-related liver disease, and fibromyalgia.

• Same is available under the following different brand names: ademetionine, adenosylmethionine, Adomet, Gumbaral, Heptral, Sadenosyl Lmethionine, sammy, Samyr

Common side effects of Same include:

• Digestive problems, such as nausea, diarrhea, or constipation.
• Mild insomnia.
• Dizziness.
• Irritability.
• Anxiety.
• Sweating.

Serious side effects of Same include:

• None

Rare side effects of Same include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Same has minor interactions with no other drugs.
• Same has severe interactions with the following drugs:
  • desvenlafaxine
  • isocarboxazid
  • linezolid
  • methylene blue
  • phenelzine
  • procarbazine
  • tranylcypromine
• Same has moderate interactions with at least 54 other drugs.
• Same has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

 Adult dosage

Suggested Dosing

Depression

• Oral: 400-1600 mg orally once a day
• IM/IV: 200-400 mg/day

Osteoarthritis

• Oral: 200 mg orally three times per day
• IV: 400 mg/day IV

Liver Disease, Alcohol-Related

• Oral: 1200-1600 mg orally once a day; no more than 24 months
• IV: 200-2000 mg/day Intravenous for 15-30 days
• IM: 200 mg/day Intramuscular for 30 days

Intrahepatic Cholestasis

• Oral: 800 mg orally two times a day

Fibromyalgia

• 800 mg orally once a day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

Contraindications

• MAO inhibitor use within 14 day

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Same?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Same?”

Cautions

• Bipolar disorder

Pregnancy and Lactation

• Information not available.

Lactation

• Information not available.