Secnidazole

Secnidazole is a prescription medication used to treat Bacterial Vaginosis and Trichomoniasis.

• Secnidazole is available under the following different brand names: Solosec.

Adult dosage

Oral granules

• 2 grams/packet

Bacterial Vaginosis

Adult dosage

• 1 packet (2 grams) of granules orally once as a single dose, without regard to timing of meals

Trichomoniasis

• 1 packet (2 grams) of granules orally once as a single dose, without regard to timing of meals

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”.

Common side effects of Secnidazole include:

• nausea,
• vomiting, 
• diarrhea, 
• stomach pain, 
• headache, and
• bitter taste in the mouth

Serious side effects of Secnidazole include:

• hives, 
• difficulty breathing, 
• swelling of the face, lips, tongue, or throat, 
• vaginal itching or burning, 
• redness or swelling, and
• white or yellow vaginal discharge (may be odorless)

Rare side effects of Secnidazole include:

• none 

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.  Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Secnidazole has severe interactions with no other drugs. 
• Secnidazole has serious interactions with the following drugs:
  • ethanol
• Secnidazole has moderate interactions with no other drugs.
• Secnidazole has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drugs interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Contraindications

• Hypersensitivity to Secnidazole, excipients of the formulation, or other nitroimidazole derivatives

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Secnidazole?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Secnidazole?”

Cautions

• Vulvovaginal candidiasis may occur; symptomatic vulvovaginal candidiasis may require treatment with an antifungal agent
• Carcinogenicity has been seen in mice and rats treated long term with nitroimidazole derivatives, which are structurally related to Secnidazole; avoid long-term use of Secnidazole
• Prescribing Secnidazole in the absence of proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria
• Avoid chronic use; carcinogenicity reported in mice and rats treated chronically with nitroimidazole derivatives, structurally related to Secnidazole; significance unclear

Drug interaction overview

• Alcohol
  • Avoid alcoholic beverages and preparations containing ethanol or propylene glycol during Secnidazole therapy and for 2 days after treatment is stopped
  • Nausea, vomiting, diarrhea, abdominal pain, dizziness, and headache were reported when coadministered

Pregnancy and Lactation

• Data with Secnidazole use in pregnant women are insufficient to inform a drug-associated risk of adverse developmental outcomes
• There is no information on the presence of Secnidazole in human milk, the effects on the breastfed child, or the effects on milk production
• Other nitroimidazole derivatives are present in human milk Because of the potential for serious adverse reactions, including tumorigenicity, advise patients that breastfeeding is not recommended during treatment with Secnidazole and for 96 hours after administration of Secnidazole