Secretin

Secretin injection is a gastrointestinal peptide hormone used for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction; stimulation of gastrin secretion to aid in the diagnosis of gastrinoma; and facilitation of the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).

• Secretin is available under the following different brand names: ChiRhoStim

Common side effects of Secretin include:

• nausea or vomiting
• flushing
• abdominal pain
• increased heart rate
• stomach upset
• anxiety
• warm or burning feeling in the stomach or abdomen
• clammy skin
• diarrhea
• faintness
• low blood pressure
• drowsiness
• tingling in legs
• Serious side effects of Secretin include:
• hives
• difficulty breathing
• swelling of the face, lips, tongue, or throat

Rare side effects of Secretin include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Injection, powder for reconstitution

• 16 mcg/vial
• 40 mcg/vial

Pancreas dysfunction

Adult dosage

• 0.2 mcg/kg IV infused over 1 minute

Gastrinoma

Adult dosage

• 0.4 mcg/kg IV infused over 1 minute

Ampulla of Vater & accessory papilla

Adult dosage

• 0.2 mcg/kg IV infused over 1 minute

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Secretin has severe interactions with no other drugs
• Secretin has serious interactions with at least 32 other drugs
• Secretin has moderate interactions with no other drugs
• Secretin has minor interactions with no other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• None

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Secretin?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Secretin?”

Cautions

• Hyporesponse: Coadministration with anticholinergic drugs may cause a hypo response to stimulation testing
• Hyper response: Coadministration of H2-receptor antagonists or PPIs may cause a hyper response in gastrin secretion in response to stimulation testing, falsely suggesting gastrinoma

Pregnancy and Lactation

• There is no available data (either clinical studies or postmarketing reports) on the use of synthetic human secretin in pregnant women.
• Animal reproduction studies have not been conducted.
• Lactation
  • There is no data on the presence of synthetic human secretin in human or animal milk.