Sodium Phosphates IV

Sodium Phosphates IV is a prescription medication used to treat hypophosphatemia.

• Sodium Phosphates IV is available under the following different brand names: N/A

Adult and pediatric dosage

• Intravenous Solution
  • Phosphorus content: 93mg (3mM)/mL
  • Sodium content: 92mg (4mEq)/mL
• Hypophosphatemia
• Adult dosage
  • Phosphorous serum level less than 0.5 mg/dL: 0.5 mmol/kg IV infused over 4-6 hours
  • Phosphorous serum level 0.5-1 mg/dL: 0.25 mmol/kg IV infused over 4-6 hours
  • Prevention of hypophosphatemia (eg, in TPN): 20-40 mmol/day IV admixed in TPN is a typical dose, but adjustment according to electrolyte levels is ongoing
• Pediatric dosage
  • Phosphorous serum level less than 0.5 mg/dL: 0.5 mmol/kg IV infused over 4-6 hours
  • Phosphorous serum level 0.5-1 mg/dL: 0.25 mmol/kg IV infused over 4-6 hours
• Prevention of hypophosphatemia (e.g., in TPN)
  • Infants/children: 0.5-2 mmol/kg/day IV
  • Children weighing over 50 kg or adolescents: 10-40 mmol/day IV
  • Dose adjustment according to electrolyte levels is ongoing

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”.

Common side effects of Sodium Phosphates IV include:

• pain, bruising, swelling, or other irritation where the injection was given, 

Serious side effects of Sodium Phosphates IV include:

• hives,
• difficult breathing, 
• swelling in the face or throat, 
• rash, 
• itching, 
• red, swollen, blistered, or peeling skin with or without fever, 
• wheezing, 
• tightness in the chest or throat, 
• trouble swallowing or talking, 
• unusual hoarseness, 
• mood changes, 
• confusion, 
• muscle pain or weakness, 
• abnormal heart rate, 
• severe dizziness, 
• fainting, 
• fast heartbeat, 
• increased thirst, 
• seizures, 
• tiredness, 
• weakness, 
• loss of appetite, 
• little or no urination, 
• dry mouth, 
• dry eyes, 
• nausea, 
• vomiting, and 
• chest pain or pressure

Rare side effects of Sodium Phosphates IV include:

• none 

This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Sodium Phosphates IV has severe interactions with the following drugs:
  • lanthanum carbonate
  • sevelamer
• Sodium Phosphates IV has serious interactions with the following drugs:
  • baloxavir marboxil
  • benazepril
  • captopril
  • erdafitinib
• Sodium Phosphates IV has moderate interactions with the following drugs:
  • calcium carbonate
  • calcium citrate
  • calcium gluconate
  • dichlorphenamide
  • furosemide
  • magnesium citrate 
  • magnesium hydroxide
  • pseudoephedrine
  • voclosporin
• Sodium Phosphates IV has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Contraindications

• Hyperphosphatemia
• Hypocalcemia
• Hypernatremia

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Sodium Phosphates IV?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Sodium Phosphates IV?”

Cautions

• Must be diluted and thoroughly mixed before administration
• Phosphorus replacement therapy with sodium phosphates should be guided primarily by the serum inorganic phosphorus levels and the limits imposed by the accompanying sodium (Na+) ion
• To avoid hypernatremia or hyperphosphatemia, infuse IV solutions containing sodium phosphates slowly
• Caution with severe renal or adrenal insufficiency due to risk for hypernatremia or hyperphosphatemia; in patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention
• Use with great care, if at all, in patients with congestive heart failure, cirrhosis, severe renal insufficiency, and other edematous conditions associated with sodium retention
• High concentrations of phosphorus may cause hypocalcemia and hypocalcemic tetany; monitor calcium levels
• Caution must be exercised in the administration of parenteral fluids, especially those containing sodium ions, to patients receiving corticosteroids or corticotropin

Aluminum toxicity

• This product contains aluminum that may be toxic; aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired; premature neonates are at particular risk because of immature kidneys; they require large amounts of calcium and phosphate solutions, which contain aluminum
• Aluminum doses exceeding 4-5 mcg/kg/day are associated with CNS and bone toxicity
• Tissue accumulation may occur at even lower doses

Pregnancy and Lactation

• Animal reproduction studies were not conducted with sodium phosphate; also not known whether sodium phosphate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; sodium phosphate should be given to a pregnant woman only if clearly needed.
• Phosphorus and sodium are normal components of human milk; the decision to administer during breastfeeding should take into account the risk of infant exposure, benefits of breastfeeding to the infant, and benefits of therapy to mother