Sodium Thiosulfate

Sodium thiosulfate is used to treat cyanide poisoning. It is also used to reduce the side effects of the cancer medication cisplatin.

The number of sodium_thiosulfate per dose can vary greatly (from 1-8 x 1010 sodium_thiosulfate/collection) based on the donor and mobilization regimen given to the donor.

Dosage Considerations – Should be Given as Follows:

Cyanide Poisoning

• Adult:12.5 g intravenous (IV) (infuse over 10-20 minutes)
• Pediatric: 7 g/m² IV (maximum 12.5 g), infuse over at least 10 minutes

Cisplatin Extravasation

• 2 mL 1/6 molar solution through IV cannula for every 100 mg cisplatin; remove needle, then inject 0.1 mL injections clockwise around extravasation area up to 1 mL; repeat several times within the 3-4 hours of extravasation incident

Cisplatin Nephrotoxicity

• 4 g/m² IV bolus followed by 12 g/m² IV infusion over 6 hours

Preparation of 1/6 Molar Solution

• 4 mL of 10% solution + 6 mL sterile water for injection
• 1.6 mL of 25% solution + 8.4 mL sterile water for injection

Administration

• Monitor for thiocyanate toxicity

Side effects of sodium thiosulfate include:

• Low blood pressure (hypotension) (infusion rate-dependent)
• Nausea/vomiting
• Disorientation
• Headache
• Prolonged bleeding therapy
• Hypersensitivity reactions
• Contact dermatitis
• Warmth
• Local irritation

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Sodium thiosulfate has no known interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

This medication contains sodium thiosulfate. Do not take sodium thiosulfate if you are allergic to sodium thiosulfate or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• No information available

Effects of Drug Abuse

No information available.

Short-Term Effects

• See "What Are Side Effects Associated with Using Sodium Thiosulfate?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Sodium Thiosulfate?"

Cautions

• No information available.

Pregnancy and Lactation

Use sodium thiosulfate with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

Consult your doctor before breastfeeding.