Strontium 89 Chloride

Strontium 89 Chloride is a radiopharmaceutical drug indicated for the relief of bone pain in patients with painful skeletal metastases.

• Strontium 89 Chloride is available under the following different brand names: Metastron

Common side effects of Strontium 89 Chloride include:

• hills
• fever
• flushing
• a mild increase in bone pain 36 to 72 hours after injection

Serious side effects of Strontium 89 Chloride include:

• hives
• difficulty breathing
• swelling of the face, lips, tongue, or throat
• black or tarry stools
• blood in the urine or stools
• cough
• hoarseness
• fever
• chills
• lower back or side pain
• painful or difficult urination
• pinpoint red spots on the skin
• unusual bleeding
• easy bruising

Rare side effects of Strontium 89 Chloride include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Injectable solution

• 1 MCi/mL

Bone pain from skeletal metastases

Adult dosage

• 148 MBq (=4 mCi) slow IV injection or
• 1.5 to 2.2 MBq/kg (= 40 to 60 uCi/kg)
• Repeat doses not recommended more frequently than 90 days interval

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Strontium 89 Chloride has no noted severe interactions with any other drugs
• Strontium 89 Chloride has no noted serious interactions with any other drugs
• Strontium 89 Chloride has no noted moderate interactions with any other drugs
• Strontium 89 Chloride has no noted minor interactions with any other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Hypersensitivity

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Strontium 89 Chloride?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Strontium 89 Chloride?”

Cautions

• Platelet less than 60,000/mm³; WBC less than 2400/mm³
• Pain relief may occur 7 to 20 days after injection
• Only for cancers involving bone
• Bone marrow toxicity may occur
• Evaluate risk/benefits in patients with renal impairment (excreted renally)
• Nor for use in patients with cancer not involving bone or short life expectancy
• Incontinent patients may require urinary catheterization to reduce radioactive contamination
• Use only under the supervision of experienced personnel

Pregnancy and Lactation

• Use in life-threatening emergencies when no safer drug is available
• Lactation
  • Excreted in breast milk