Arec, Aréca, Areca catechu, Areca Nut, Areca Palm, Arecanut Palm, Aréquier, Betel Nut, Betel Quid, Betelnut Palm, Bing Lang, Chique de Bétel, Gubak, Noix de Bétel, Nuez de Areca, Nuez de Betel, Palmier d'Arec, Palmier à Bétel, Palmier à Canne Jaune, Palmier Doré, Pinag, Pinang Palm, Pinlag, Poogiphalam, Puga, Supari, Tantusara.
Areca is a plant. The nut is used to make medicine. Areca nut is chewed alone or in the form of quids, a mixture of tobacco, powdered or sliced areca nut, and slaked lime wrapped in the leaf of “betel” vine (Piper betel).
Areca is used for treatment of a mental disorder called schizophrenia and an eye disorder called glaucoma; as a mild stimulant; and as a digestive aid.
Some people use areca as a recreational drug because it speeds up the central nervous system (CNS).
In veterinary medicine, an extract of areca is used for expelling tapeworms in cattle, dogs, and horses; to empty animals' bowels; and for treating intestinal colic in horses.
How does work?
It is thought that areca affects chemicals in the brain and other parts of the central nervous system.
Insufficient Evidence to Rate Effectiveness for...
- Schizophrenia. Early research suggests that betel nut might be helpful for schizophrenia. Some patients with schizophrenia who chew betel nut seem to have less severe symptoms.
- Stroke. Early research suggests that taking a solution containing betel nut extract might improve speech, strength, and bladder function in people who have had a stroke.
- Glaucoma.
- Aiding in digestion.
- Other conditions.
QUESTION
Next to red peppers, you can get the most vitamin C from ________________. See AnswerNot enough is known about the safety of taking betel nut by mouth short-term. However, betel nut is considered LIKELY UNSAFE when taken by mouth long-term or in high doses. Some of the chemicals in betel nut have been associated with cancer. Other chemicals are poisonous.
Eating 8-30 grams of betel nut can cause death. Chewing betel nut can make your mouth, lips, and stool turn red. It can cause stimulant effects similar to caffeine and tobacco use. It can also cause more severe effects including vomiting, diarrhea, gum problems, increased saliva, chest pain, abnormal heart beats, low blood pressure, shortness of breath and rapid breathing, heart attack, coma, and death.
Pregnancy and breast-feeding: Taking betel nut by mouth is LIKELY UNSAFE for anyone, due to concerns about cancer and toxicity. But pregnant and breast-feeding women have additional risks. Betel nut can affect the central nervous system and this might endanger a pregnancy. Chemicals in betel nut might pass into breast milk and harm a nursing infant. Stay on the safe side and avoid using betel nut if you are pregnant or breast-feeding.
Asthma: Betel nut might make asthma worse.
Slow heart rate (bradycardia): Betel nut might slow down the heart beat. This could be a problem in people who already have a slow heart rate.
Gastrointestinal tract blockage: Betel nut might cause “congestion” in the intestines. This might cause problems in people who have a blockage in their intestines.
Ulcers: Betel nut might increase secretions in the stomach and intestines. There is concern that this could worsen ulcers.
Lung conditions: Betel nut might increase fluid secretions in the lung. There is concern that this could worsen lung conditions, such as asthma or emphysema.
Seizures: There is concern that betel nut might increase the risk of seizures.
Urinary tract obstruction: Betel nut might increase secretions in the urinary tract. There is concern that this could worsen urinary obstruction.
Drying medications (Anticholinergic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Betel nut contains chemicals that can affect the brain and heart. Some drying medications can also affect the brain and heart. But betel nut works differently than drying medications. Betel nut might decrease the effects of drying medications.
Some of these drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).
Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Betel nut might increase certain chemicals in the brain, heart, and elsewhere in the body. Some medications used for Alzheimer's disease also affect these chemicals. Taking betel nut along with medications for Alzheimer's disease might increase effects and side effects of medications used for Alzheimer's disease.
Medications for depression (MAOIs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Betel nut might increase the amount of a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking betel nut with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
ProcyclidineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Procyclidine can affect chemicals in the body. Betel nut can also affect chemicals in the body. But betel nut has the opposite effect of procyclidine. Taking betel nut along with procyclidine might decrease the effectiveness of procyclidine.
Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Betel nut contains a chemical that affects the body. This chemical is similar to some medications used for glaucoma, Alzheimer's disease, and other conditions. Taking betel nut with these medications might increase the chance of side effects.
Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), donepezil (Aricept), tacrine (Cognex), and others.
The appropriate dose of areca depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for areca. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
SLIDESHOW
Vitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowNatural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Allen, S. E., Singh, S., and Robertson, W. G. The increased risk of urinary stone disease in betel quid chewers. Urol Res 2006;34(4):239-243. View abstract.
Anil, S. and Beena, V. T. Oral submucous fibrosis in a 12-year-old girl: case report. Pediatr.Dent 1993;15(2):120-122. View abstract.
Ashby, J., Styles, J. A., and Boyland, E. Betel nuts, arecaidine, and oral cancer. Lancet 1979;1(8107):112. View abstract.
Awang, M. N. Fate of betel nut chemical constituents following nut treatment prior to chewing and its relation to oral precancerous & cancerous lesion. Dent J Malays. 1988;10(1):33-37. View abstract.
Babu, S., Bhat, R. V., Kumar, P. U., Sesikaran, B., Rao, K. V., Aruna, P., and Reddy, P. R. A comparative clinico-pathological study of oral submucous fibrosis in habitual chewers of pan masala and betelquid. J Toxicol.Clin Toxicol. 1996;34(3):317-322. View abstract.
Bhisey, R. A., Ramchandani, A. G., D'Souza, A. V., Borges, A. M., and Notani, P. N. Long-term carcinogenicity of pan masala in Swiss mice. Int J Cancer 11-26-1999;83(5):679-684. View abstract.
Boucher, B. J., Ewen, S. W., and Stowers, J. M. Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring. Diabetologia 1994;37(1):49-55. View abstract.
Chakarvarti SK, Dhiman J, and Nagpaul KK. Uranium trace analysis of a chewable betel-leaf preparation and tea-leaves. Health Physics 1981;40:78-81.
Chakrabarti, R. N., Dutta, K., Ghosh, K., and Sikdar, S. Uterine cervical dysplasia with reference to the betel quid chewing habit. Eur J Gynaecol.Oncol 1990;11(1):57-59. View abstract.
Chang, K. W., Lee, T. C., Yeh, W. I., Chung, M. Y., Liu, C. J., Chi, L. Y., and Lin, S. C. Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br J Cancer 10-18-2004;91(8):1551-1555. View abstract.
Chang, L. Y., Wan, H. C., Lai, Y. L., Liu, T. Y., and Hung, S. L. Enhancing effects of areca nut extracts on the production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells. J Periodontol. 2006;77(12):1969-1977. View abstract.
Chang, M. C., Ho, Y. S., Lee, P. H., Chan, C. P., Lee, J. J., Hahn, L. J., Wang, Y. J., and Jeng, J. H. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 2001;22(9):1527-1535. View abstract.
Chang, M. C., Kuo, M. Y., Hahn, L. J., Hsieh, C. C., Lin, S. K., and Jeng, J. H. Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts. J Periodontol. 1998;69(10):1092-1097. View abstract.
Chang, W. C., Hsiao, C. F., Chang, H. Y., Lan, T. Y., Hsiung, C. A., Shih, Y. T., and Tai, T. Y. Betel nut chewing and other risk factors associated with obesity among Taiwanese male adults. Int J Obes.(Lond) 2006;30(2):359-363. View abstract.
Chang, Y. C., Hu, C. C., Lii, C. K., Tai, K. W., Yang, S. H., and Chou, M. Y. Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro. Clin Oral Investig. 2001;5(1):51-56. View abstract.
Chang, Y. C., Tai, K. W., Lii, C. K., Chou, L. S., and Chou, M. Y. Cytopathologic effects of arecoline on human gingival fibroblasts in vitro. Clin Oral Investig. 1999;3(1):25-29. View abstract.
Chatrchaiwiwatana, S. Dental caries and periodontitis associated with betel quid chewing: analysis of two data sets. J Med Assoc Thai. 2006;89(7):1004-1011. View abstract.
Chaudhry, K. Is pan masala-containing tobacco carcinogenic? Natl.Med J India 1999;12(1):21-27. View abstract.
Chempakam, B. Hypoglycaemic activity of arecoline in betel nut Areca catechu L. Indian J Exp Biol 1993;31(5):474-475. View abstract.
Chen, C. C., Huang, J. F., and Tsai, C. C. In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids. Gaoxiong Yi Xue Ke Xue Za Zhi 1995;11(11):604-614. View abstract.
Chen, G. S. and Chen, C. H. [A statistical analysis of oral squamous cell carcinoma]. Gaoxiong.Yi Xue.Ke.Xue.Za Zhi 1995;11(10):582-588. View abstract.
Chen, P. H., Tsai, C. C., Lin, Y. C., Ko, Y. C., Yang, Y. H., Shieh, T. Y., Ho, P. S., Li, C. M., Min-Shan, Ko A., and Chen, C. H. Ingredients contribute to variation in production of reactive oxygen species by areca quid. J Toxicol Environ.Health A 2006;69(11):1055-1069. View abstract.
Chiang, W. T., Yang, C. C., Deng, J. F., and Bullard, M. Cardiac arrhythmia and betel nut chewing--is there a causal effect? Vet.Hum.Toxicol. 1998;40(5):287-289. View abstract.
Chin, C. T. and Lee, K. W. The effects of betel-nut chewing on the buccal mucosa of 296 Indians and Malays in West Malaysia. A clinical study. Br J Cancer 1970;24(3):427-432. View abstract.
Chitra, S., Ashok, L., Anand, L., Srinivasan, V., and Jayanthi, V. Risk factors for esophageal cancer in Coimbatore, southern India: a hospital-based case-control study. Indian J Gastroenterol. 2004;23(1):19-21. View abstract.
Chu, N. S. Betel chewing increases the skin temperature: effects of atropine and propranolol. Neurosci.Lett. 7-14-1995;194(1-2):130-132. View abstract.
Chu, N. S. Cardiovascular responses to betel chewing. J Formos.Med Assoc 1993;92(9):835-837. View abstract.
Chu, N. S. Effect of betel chewing on performance reaction time. J Formos.Med Assoc 1994;93(4):343-345. View abstract.
Chu, N. S. Effect of betel chewing on RR interval variation. J Formos.Med Assoc 1995;94(3):106-110. View abstract.
Chu, N. S. Effects of betel chewing on electroencephalographic activity: spectral analysis and topographic mapping. J Formos.Med Assoc 1994;93(2):167-169. View abstract.
Chu, N. S. Effects of Betel chewing on the central and autonomic nervous systems. J Biomed.Sci. 2001;8(3):229-236. View abstract.
Chu, N. S. Sympathetic response to betel chewing. J Psychoactive Drugs 1995;27(2):183-186. View abstract.
Chung, C. H., Yang, Y. H., Wang, T. Y., Shieh, T. Y., and Warnakulasuriya, S. Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan. J Oral Pathol Med 2005;34(8):460-466. View abstract.
Chung, F. M., Chang, D. M., Chen, M. P., Tsai, J. C., Yang, Y. H., Shieh, T. Y., Shin, S. J., Chen, T. H., Tai, T. Y., and Lee, Y. J. Areca nut chewing is associated with metabolic syndrome: role of tumor necrosis factor-alpha, leptin, and white blood cell count in betel nut chewing-related metabolic derangements. Diabetes Care 2006;29(7):1714. View abstract.
Cunningham, L., Worrel, T., and Leflore, J. Acute lead poisoning from the betel nut. A case report. J Tenn Med Assoc 1985;78(8):491-492. View abstract.
Daftary, D. K., Bhonsle, R. B., Murti, R. B., Pindborg, J. J., and Mehta, F. S. An oral lichen planus-like lesion in Indian betel-tobacco chewers. Scand J Dent Res 1980;88(3):244-249. View abstract.
Dar, A. and Khatoon, S. Behavioral and biochemical studies of dichloromethane fraction from the Areca catechu nut. Pharmacol Biochem Behav. 1-1-2000;65(1):1-6. View abstract.
Dasgupta, R., Saha, I., Pal, S., Bhattacharyya, A., Sa, G., Nag, T. C., Das, T., and Maiti, B. R. Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice. Toxicology 10-3-2006;227(1-2):94-104. View abstract.
Dave, B. J., Trivedi, A. H., and Adhvaryu, S. G. In vitro genotoxic effects of areca nut extract and arecoline. J Cancer Res Clin Oncol 1992;118(4):283-288. View abstract.
Dave, B. J., Trivedi, A. H., and Adhvaryu, S. G. Role of areca nut consumption in the cause of oral cancers. A cytogenetic assessment. Cancer 9-1-1992;70(5):1017-1023. View abstract.
de Miranda, C. M., van Wyk, C. W., van der, Biji P., and Basson, N. J. The effect of areca nut on salivary and selected oral microorganisms. Int Dent.J 1996;46(4):350-356. View abstract.
Deahl MP. Psychostimulant properties of betel nuts. BMJ 1987;294:841.
Deahl, M. Betel nut-induced extrapyramidal syndrome: an unusual drug interaction. Mov Disord. 1989;4(4):330-332. View abstract.
Deng, J. F., Ger, J., Tsai, W. J., Kao, W. F., and Yang, C. C. Acute toxicities of betel nut: rare but probably overlooked events. J Toxicol Clin Toxicol 2001;39(4):355-360. View abstract.
Dowse, G. K. Betel-nut chewing and diabetes in Papua New Guinea and elsewhere. Diabetologia 1994;37(10):1062-1064. View abstract.
Epstein, R. J., Leung, T. W., and Cheung, P. S. Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy. Cancer Chemother.Pharmacol 2006;58(6):835-837. View abstract.
Fasanmade, A., Kwok, E., and Newman, L. Oral squamous cell carcinoma associated with khat chewing. Oral Surg Oral Med Oral Pathol Oral Radiol.Endod. 2007;104(1):e53-e55. View abstract.
Fendell, L. D. and Smith, J. R. Betel-nut-associated cancer: report of case. J Oral Surg 1970;28(6):455-456. View abstract.
Frewer, L. J. The effect of betel nut on human performance. P N G Med J 1990;33(2):143-145. View abstract.
Gerreth, K. [Tooth wear in Hindu betel nut chewers]. Przegl.Lek. 2006;63(10):882-886. View abstract.
Guh, J. Y., Chen, H. C., Tsai, J. F., and Chuang, L. Y. Betel-quid use is associated with heart disease in women. Am J Clin Nutr 2007;85(5):1229-1235. View abstract.
Guh, J. Y., Chuang, L. Y., and Chen, H. C. Betel-quid use is associated with the risk of the metabolic syndrome in adults. Am J Clin Nutr 2006;83(6):1313-1320. View abstract.
Hafeman, D., Ahsan, H., Islam, T., and Louis, E. Betel quid: Its tremor-producing effects in residents of Araihazar, Bangladesh. Mov Disord 2006;21(4):567-571. View abstract.
Hanley, M. R. and Iversen, L. L. Muscarinic cholinergic receptors in rat corpus striatum and regulation of guanosine cyclic 3',5'-monophosphate. Mol Pharmacol 1978;14(2):246-255. View abstract.
Harvey, W., Scutt, A., Meghji, S., and Canniff, J. P. Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. Arch Oral Biol 1986;31(1):45-49. View abstract.
Hazare, V. K., Goel, R. R., and Gupta, P. C. Oral submucous fibrosis, areca nut and pan masala use: a case-control study. Natl.Med J India 1998;11(6):299. View abstract.
Hazarey, V. K., Erlewad, D. M., Mundhe, K. A., and Ughade, S. N. Oral submucous fibrosis: study of 1000 cases from central India. J Oral Pathol Med 2007;36(1):12-17. View abstract.
Ho, T. J., Chiang, C. P., Hong, C. Y., Kok, S. H., Kuo, Y. S., and Yen-Ping, Kuo M. Induction of the c-jun protooncogene expression by areca nut extract and arecoline on oral mucosal fibroblasts. Oral Oncol. 2000;36(5):432-436. View abstract.
Howden, G. F. The cariostatic effect of betel nut chewing. P N G Med J 1984;27(3-4):123-131. View abstract.
Huang, Z., Xiao, B., Wang, X., Li, Y., and Deng, H. Betel nut indulgence as a cause of epilepsy. Seizure. 2003;12(6):406-408. View abstract.
Hung, D. Z. and Deng, J. F. Acute myocardial infarction temporally related to betel nut chewing. Vet.Hum.Toxicol. 1998;40(1):25-28. View abstract.
Hung, S. L., Chen, Y. L., Wan, H. C., Liu, T. Y., Chen, Y. T., and Ling, L. J. Effects of areca nut extracts on the functions of human neutrophils in vitro. J Periodontal Res 2000;35(4):186-193. View abstract.
Hung, S. L., Lee, Y. Y., Liu, T. Y., Peng, J. L., Cheng, Y. Y., and Chen, Y. T. Modulation of phagocytosis, chemotaxis, and adhesion of neutrophils by areca nut extracts. J Periodontol. 2006;77(4):579-585. View abstract.
Inokuchi, J., Okabe, H., Yamauchi, T., Nagamatsu, A., Nonaka, G., and Nishioka, I. Antihypertensive substance in seeds of Areca catechu L. Life Sci 4-14-1986;38(15):1375-1382. View abstract.
Jeng, J. H., Chang, M. C., and Hahn, L. J. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol. 2001;37(6):477-492. View abstract.
Jeng, J. H., Hahn, L. J., Lin, B. R., Hsieh, C. C., Chan, C. P., and Chang, M. C. Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. J Oral Pathol.Med 1999;2(28):64-71. View abstract.
Jeng, J. H., Ho, Y. S., Chan, C. P., Wang, Y. J., Hahn, L. J., Lei, D., Hsu, C. C., and Chang, M. C. Areca nut extract up-regulates prostaglandin production, cyclooxygenase- 2 mRNA and protein expression of human oral keratinocytes. Carcinogenesis 2000;21(7):1365-1370. View abstract.
Jeng, J. H., Kuo, M. L., Hahn, L. J., and Kuo, M. Y. Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro. J Dent Res. 1994;73(5):1043-1049. View abstract.
Jeon, S. M., Kim, H. S., Lee, T. G., Ryu, S. H., Suh, P. G., Byun, S. J., Park, Y. B., and Choi, M. S. Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract. Ann Nutr Metab 2000;44(4):170-176. View abstract.
Johnston, G. A., Krogsgaard-Larsen, P., and Stephanson, A. Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake. Nature 12-18-1975;258(5536):627-628. View abstract.
Kiyingi KS and Saweri A. Betelnut chewing causes bronchoconstriction in some asthma patients. PNG Med J 1994;37(2):90-99.
Kiyingi, K. S. Betel-nut chewing may aggravate asthma. PNG Med J 1991;34(2):117-121. View abstract.
Kiyingi, K. S. Slaked lime and betel nut cancer in Papua New Guinea. Lancet 11-28-1992;340(8831):1357-1358. View abstract.
Kumar, M., Kannan, A., and Upreti, R. K. Effect of betel/areca nut (Areca catechu) extracts on intestinal epithelial cell lining. Vet.Hum.Toxicol. 2000;42(5):257-260. View abstract.
Kumpawat, K., Deb, S., Ray, S., and Chatterjee, A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. Mutat.Res. 7-8-2003;538(1-2):1-12. View abstract.
Kuo, F. C., Wu, D. C., Yuan, S. S., Hsiao, K. M., Wang, Y. Y., Yang, Y. C., and Lo, Y. C. Effects of arecoline in relaxing human umbilical vessels and inhibiting endothelial cell growth. J Perinat Med 2005;33(5):399-405. View abstract.
Kuo, R. C., Lin, C. Y., and Kuo, M. Y. Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. J Formos.Med Assoc 2006;105(3):229-234. View abstract.
Kuruppuarachchi, K. A. and Williams, S. S. Betel use and schizophrenia. Br.J.Psychiatry 2003;182:455. View abstract.
Lai, C. S., Shieh, T. Y., Yang, Y. H., Chong, M. Y., Hung, H. C., and Tsai, C. C. Factors associated with quitting areca (betel) quid chewing. Community Dent Oral Epidemiol. 2006;34(6):467-474. View abstract.
Lai, K. C. and Lee, T. C. Genetic damage in cultured human keratinocytes stressed by long-term exposure to areca nut extracts. Mutat.Res 7-25-2006;599(1-2):66-75. View abstract.
Lai, Y. L., Lin, J. C., Yang, S. F., Liu, T. Y., and Hung, S. L. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodontal Res 2007;42(1):69-76. View abstract.
Lan, T. Y., Chang, W. C., Tsai, Y. J., Chuang, Y. L., Lin, H. S., and Tai, T. Y. Areca nut chewing and mortality in an elderly cohort study. Am J Epidemiol. 3-15-2007;165(6):677-683. View abstract.
Lee, C. N., Jayanthi, V., McDonald, B., Probert, C. S., and Mayberry, J. F. Betel nut and smoking. Are they both protective in ulcerative colitis? A pilot study. Arq Gastroenterol. 1996;33(1):3-5. View abstract.
Lee, H. C., Yin, P. H., Yu, T. N., Chang, Y. D., Hsu, W. C., Kao, S. Y., Chi, C. W., Liu, T. Y., and Wei, Y. H. Accumulation of mitochondrial DNA deletions in human oral tissues -- effects of betel quid chewing and oral cancer. Mutat.Res 6-27-2001;493(1-2):67-74. View abstract.
Li, S. M., Huang, J. S., and Wu, S. C. The outcome expectancy model for areca-quid chewing behavior. Addict.Behav 2007;32(3):628-633. View abstract.
Liao, C. T., Chen, I. H., Chang, J. T., Wang, H. M., Hsieh, L. L., and Cheng, A. J. Lack of correlation of betel nut chewing, tobacco smoking, and alcohol consumption with telomerase activity and the severity of oral cancer. Chang Gung.Med.J. 2003;26(9):637-645. View abstract.
Liao, Y. L., Chiang, Y. C., Tsai, T. F., Lee, R. F., Chan, Y. C., and Hsiao, C. H. Contact leukomelanosis induced by the leaves of Piper betel L. (Piperaceae): a clinical and histopathologic survey. J Am Acad.Dermatol. 1999;40(4):583-589. View abstract.
Lin, M. H., Chou, F. P., Huang, H. P., Hsu, J. D., Chou, M. Y., and Wang, C. J. The tumor promoting effect of lime-piper betel quid in JB6 cells. Food Chem.Toxicol. 2003;41(11):1463-1471. View abstract.
Liou, S. H., Wu, T. N., Chiang, H. C., Yang, G. Y., Wu, Y. Q., Lai, J. S., Ho, S. T., Guo, Y. L., Ko, Y. C., and Chang, P. Y. Blood lead levels in the general population of Taiwan, Republic of China. Int Arch.Occup Environ Health 1994;66(4):255-260. View abstract.
Liu, C. J., Chen, C. L., Chang, K. W., Chu, C. H., and Liu, T. Y. Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report. CMAJ. 2-8-2000;162(3):359-360. View abstract.
Liu, T. Y., Chen, C. L., and Chi, C. W. Oxidative damage to DNA induced by areca nut extract. Mutat.Res. 1996;367(1):25-31. View abstract.
Lodge, D., Johnston, G. A., Curtis, D. R., and Brand, S. J. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res 11-18-1977;136(3):513-522. View abstract.
Lu, S. Y., Chang, K. W., Liu, C. J., Tseng, Y. H., Lu, H. H., Lee, S. Y., and Lin, S. C. Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte. Carcinogenesis 2006;27(6):1273-1284. View abstract.
Maher, R., Lee, A. J., Warnakulasuriya, K. A., Lewis, J. A., and Johnson, N. W. Role of areca nut in the causation of oral submucous fibrosis: a case- control study in Pakistan. J Oral Pathol.Med 1994;23(2):65-69. View abstract.
Mannan MA, Mohammad QD, Haqua A, and et al. Role of areca-catechu (betel-nut) in cerebrovascular disease: a double blind clinical trial. Bangladesh J Neuro 1988;4(2):46-51.
Mannan MA. Areca catechu for treatment of cerebrovascular disease (CVD). Neuroscience 1987;22(Suppl):S539.
Mannan, N., Boucher, B. J., and Evans, S. J. Increased waist size and weight in relation to consumption of Areca catechu (betel-nut); a risk factor for increased glycaemia in Asians in east London. Br J Nutr 2000;83(3):267-273. View abstract.
McCarty, K. M., Houseman, E. A., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Smith, T., Ryan, L., and Christiani, D. C. The impact of diet and betel nut use on skin lesions associated with drinking-water arsenic in Pabna, Bangladesh. Environ.Health Perspect. 2006;114(3):334-340. View abstract.
Metha FS and et al. Relation of betel leaf chewing to periodontal disease. JADA 1955;50(5):531-536.
Moller, I. J., Pindborg, J. J., and Effendi, I. The relation between betel chewing and dental caries. Scand J Dent Res 1977;85(1):64-70. View abstract.
Mukherjee, A., Chakrabarti, J., Chakrabarti, A., Banerjee, T., and Sarma, A. Effect of 'Pan Masala' on the germ cells of male mice. Cancer Lett 7-4-1991;58(3):161-165. View abstract.
Murlidhar V and Upmanyu G. Tobacco chewing, oral submucous fibrosis, and anaesthetic risk. Lancet 1996;347:1840.
Nair, U. J., Friesen, M., Richard, I., MacLennan, R., Thomas, S., and Bartsch, H. Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro. Carcinogenesis 1990;11(12):2145-2148. View abstract.
Nair, U. J., Nair, J., Friesen, M. D., Bartsch, H., and Ohshima, H. Ortho- and meta-tyrosine formation from phenylalanine in human saliva as a marker of hydroxyl radical generation during betel quid chewing. Carcinogenesis 1995;16(5):1195-1198. View abstract.
Nelson, B. S. and Heischober, B. Betel nut: a common drug used by naturalized citizens from India, Far East Asia, and the South Pacific Islands. Ann.Emerg.Med 1999;34(2):238-243. View abstract.
Norton, S. A. Betel: consumption and consequences. J Am Acad.Dermatol. 1998;38(1):81-88. View abstract.
Nunez-de la Mora, A., Chatterton, R. T., Mateo, E. T., Jesmin, F., and Bentley, G. R. Effect of chewing betel nut on measurements of salivary progesterone and estradiol. Am J Phys.Anthropol. 2007;132(2):311-315. View abstract.
Nutt, J. G., Rosin, A., and Chase, T. N. Treatment of Huntington disease with a cholinergic agonist. Neurology 1978;28(10):1061-1064. View abstract.
Oakley, E., Demaine, L., and Warnakulasuriya, S. Areca (betel) nut chewing habit among high-school children in the Commonwealth of the Northern Mariana Islands (Micronesia). Bull.World Health Organ 2005;83(9):656-660. View abstract.
Ogunkolade, W. B., Boucher, B. J., Bustin, S. A., Burrin, J. M., Noonan, K., Mannan, N., and Hitman, G. A. Vitamin D metabolism in peripheral blood mononuclear cells is influenced by chewing "betel nut" (Areca catechu) and vitamin D status. J Clin Endocrinol.Metab 2006;91(7):2612-2617. View abstract.
Ozkan, O., Mardini, S., Chen, H. C., Cigna, E., Tang, W. R., and Liu, Y. T. Repair of buccal defects with anterolateral thigh flaps. Microsurgery 2006;26(3):182-189. View abstract.
Panda, S. and Kar, A. Dual role of betel leaf extract on thyroid function in male mice. Pharmacol Res 1998;38(6):493-496. View abstract.
Pearson, N., Croucher, R., Marcenes, W., and O'Farrell, M. Prevalence of oral lesions among a sample of Bangladeshi medical users aged 40 years and over living in Tower Hamlets, UK. Int Dent.J 2001;51(1):30-34. View abstract.
Phukan, R. K., Ali, M. S., Chetia, C. K., and Mahanta, J. Betel nut and tobacco chewing; potential risk factors of cancer of oesophagus in Assam, India. Br J Cancer 2001;85(5):661-667. View abstract.
Pickwell, S. M., Schimelpfening, S., and Palinkas, L. A. 'Betelmania'. Betel quid chewing by Cambodian women in the United States and its potential health effects. West J Med 1994;160(4):326-330. View abstract.
Pillai, K. G. and Burde, K. N. Increased copper level in oral mucosal tissue of patients with submucous fibrosis and who chew areca nut products. West Indian Med J 2005;54(4):270-271. View abstract.
Raghavan V and Baruah HK. Arecanut: India's popular masticatory--history, chemistry and utilization. Economic Botany 1958;12:315-345.
Raisuddin, S. and Misra, J. K. Aflatoxin in betel nut and its control by use of food preservatives. Food Addit.Contam 1991;8(6):707-712. View abstract.
Raja, K. B., Hazarey, V. K., Peters, T. J., and Warnakulasuriya, S. Effect of areca nut on salivary copper concentration in chronic chewers. Biometals 2007;20(1):43-47. View abstract.
Rao, A. R. and Das, P. Evaluation of the carcinogenicity of different preparations of areca nut in mice. Int J Cancer 4-15-1989;43(4):728-732. View abstract.
Rao, M. B. and Rao, C. B. Incidence of tempero-mandibular joint pain dysfunction syndrome in rural population. Int J Oral Surg. 1981;10(4):261-265. View abstract.
Reichart, P. A. and Philipsen, H. P. [Oral submucous fibrosis in a 31-year-old Indian women: first case report from Germany]. Mund Kiefer Gesichtschir. 2006;10(3):192-196. View abstract.
Schamschula, R. G., Adkins, B. L., Barmes, D. E., and Charlton, G. Betal chewing and caries experience in New Guinea. Community Dent.Oral Epidemiol 1977;5(6):284-286. View abstract.
Schullian D. Notes and Events. J Hist Med 1984;39:65-68.
Seedat, H. A. and van Wyk, C. W. Betel chewing and dietary habits of chewers without and with submucous fibrosis and with concomitant oral cancer. S.Afr.Med J 12-3-1988;74(11):572-575. View abstract.
Seedat, H. A. and van Wyk, C. W. Betel-nut chewing and submucous fibrosis in Durban. S.Afr.Med J 12-3-1988;74(11):568-571. View abstract.
Seedat, H. A. and van Wyk, C. W. Submucous fibrosis (SF) in ex-betel nut chewers: a report of 14 cases. J Oral Pathol 1988;17(5):226-229. View abstract.
Seedat, H. A. and van Wyk, C. W. The oral features of betel nut chewers without submucous fibrosis. J Biol Buccale 1988;16(3):123-128. View abstract.
Shah, N. and Sharma, P. P. Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study. J Oral Pathol Med 1998;27(10):475-479. View abstract.
Sharma, A. K., Gupta, R., Gupta, H. P., and Singh, A. K. Haemodynamic effects of pan masala in healthy volunteers. J Assoc Physicians India 2000;48(4):400-401. View abstract.
Sheikh, M. Y., Rizvi, I. H., and Ahmed, I. Oesophageal carcinoma caused by betel nut. J Pak.Med Assoc 1992;42(6):145-146. View abstract.
Shirname, L. P., Menon, M. M., Nair, J., and Bhide, S. V. Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients. Nutr.Cancer 1983;5(2):87-91. View abstract.
Shiu, M. N., Chen, T. H., Chang, S. H., and Hahn, L. J. Risk factors for leukoplakia and malignant transformation to oral carcinoma: a leukoplakia cohort in Taiwan. Br J Cancer 2000;82(11):1871-1874. View abstract.
Singh, A. and Rao, A. R. Modulatory effect of Areca nut on the action of mace (Myristica fragrans, Houtt) on the hepatic detoxification system in mice. Food Chem Toxicol 1993;31(7):517-521. View abstract.
Sinor, P. N., Gupta, P. C., Murti, P. R., Bhonsle, R. B., Daftary, D. K., Mehta, F. S., and Pindborg, J. J. A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut. J Oral Pathol.Med 1990;19(2):94-98. View abstract.
Smythies, J. R. Betel nut as a GABA blocker. Am J Psychiatry 1977;134(7):822. View abstract.
Srivatanakul, P., Parkin, D. M., Khlat, M., Chenvidhya, D., Chotiwan, P., Insiripong, S., L'Abbe, K. A., and Wild, C. P. Liver cancer in Thailand. II. A case-control study of hepatocellular carcinoma. Int J Cancer 5-30-1991;48(3):329-332. View abstract.
Stoopler, E. T., Parisi, E., and Sollecito, T. P. Betel quid-induced oral lichen planus: a case report. Cutis 2003;71(4):307-311. View abstract.
Stricherz, M. E. and Pratt, P. Betel quid and reaction time. Pharmacol Biochem.Behav. 1976;4(5):627-628. View abstract.
Sullivan, R. J., Andres, S., Otto, C., Miles, W., and Kydd, R. The effects of an indigenous muscarinic drug, Betel nut (Areca catechu), on the symptoms of schizophrenia: a longitudinal study in Palau, Micronesia. Am J Psychiatry 2007;164(4):670-673. View abstract.
Sundqvist, K. and Grafstrom, R. C. Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells. Int J Cancer 9-9-1992;52(2):305-310. View abstract.
Talonu, N. T. Observations on betel-nut use, habituation, addiction and carcinogenesis in Papua New Guineans. P.N G.Med J 1989;32(3):195-197. View abstract.
Tang, J. G., Jian, X. F., Gao, M. L., Ling, T. Y., and Zhang, K. H. Epidemiological survey of oral submucous fibrosis in Xiangtan City, Hunan Province, China. Community Dent Oral Epidemiol. 1997;25(2):177-180. View abstract.
Taufa T. Betel-Nut Chewing and Pregnancy. Papua New Guinea Med J 1988;31:229-233.
Taylor, R. F., al-Jarad, N., John, L. M., Conroy, D. M., and Barnes, N. C. Betel-nut chewing and asthma. Lancet 5-9-1992;339(8802):1134-1136. View abstract.
Tennekoon, G. E. and Bartlett, G. C. Effect of betel chewing on the oral mucosa. Br.J Cancer 1969;23(1):39-43. View abstract.
Thomas, S. J. and MacLennan, R. Slaked lime and betel nut cancer in Papua New Guinea. Lancet 9-5-1992;340(8819):577-578. View abstract.
Trivedy, C., Baldwin, D., Warnakulasuriya, S., Johnson, N., and Peters, T. Copper content in Areca catechu (betel nut) products and oral submucous fibrosis. Lancet 5-17-1997;349(9063):1447. View abstract.
Tsai, J. F., Chuang, L. Y., Jeng, J. E., Ho, M. S., Hsieh, M. Y., Lin, Z. Y., and Wang, L. Y. Betel quid chewing as a risk factor for hepatocellular carcinoma: a case-control study. Br J Cancer 3-2-2001;84(5):709-713. View abstract.
Tseng, C. H. Betel nut chewing is independently associated with urinary albumin excretion rate in type 2 diabetic patients. Diabetes Care 2006;29(2):462-463. View abstract.
Tu, H. F., Liu, C. J., Chang, C. S., Lui, M. T., Kao, S. Y., Chang, C. P., and Liu, T. Y. The functional (-1171 5A-->6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users. J Oral Pathol Med 2006;35(2):99-103. View abstract.
Tung, T. H., Chiu, Y. H., Chen, L. S., Wu, H. M., Boucher, B. J., and Chen, T. H. A population-based study of the association between areca nut chewing and type 2 diabetes mellitus in men (Keelung Community-based Integrated Screening programme No. 2). Diabetologia 2004;47(10):1776-1781. View abstract.
Van Wyck CW, Olivier A, De Miranda CM, and et al. Observations on the effect of areca nut exracts on oral fibroblast proliferation. J Oral Pathol Med 1994;23(4):145-148.
van Wyk, C. W., Stander, I., Padayachee, A., and Grobler-Rabie, A. F. The areca nut chewing habit and oral squamous cell carcinoma in South African Indians. A retrospective study. S.Afr.Med J 1993;83(6):425-429. View abstract.
Vimokesant, S. L., Hilker, D. M., Nakornchai, S., Rungruangsak, K., and Dhanamitta, S. Effects of betel nut and fermented fish on the thiamin status of northeastern Thais. Am J Clin Nutr 1975;28(12):1458-1463. View abstract.
Westermeyer J. Betel Nut Chewing. JAMA 1982;248(15):1835.
Wiesner, D. M. Betel-nut withdrawal. Med J Aust. 4-20-1987;146(8):453. View abstract.
Wilson, L. G. Cross-cultural differences in indicators of improvement from psychosis: the case of betel nut chewing. J Nerv.Ment.Dis. 1979;167(4):250-251. View abstract.
Wu, I. C., Lu, C. Y., Kuo, F. C., Tsai, S. M., Lee, K. W., Kuo, W. R., Cheng, Y. J., Kao, E. L., Yang, M. S., and Ko, Y. C. Interaction between cigarette, alcohol and betel nut use on esophageal cancer risk in Taiwan. Eur J Clin Invest 2006;36(4):236-241. View abstract.
Wu, K. D., Chuang, R. B., Wu, F. L., Hsu, W. A., Jan, I. S., and Tsai, K. S. The milk-alkali syndrome caused by betelnuts in oyster shell paste. J Toxicol Clin Toxicol 1996;34(6):741-745. View abstract.
Wu, M. T., Lee, Y. C., Chen, C. J., Yang, P. W., Lee, C. J., Wu, D. C., Hsu, H. K., Ho, C. K., Kao, E. L., and Lee, J. M. Risk of betel chewing for oesophageal cancer in Taiwan. Br J Cancer 2001;85(5):658-660. View abstract.
Wu, P. A., Loh, C. H., Hsieh, L. L., Liu, T. Y., Chen, C. J., and Liou, S. H. Clastogenic effect for cigarette smoking but not areca quid chewing as measured by micronuclei in exfoliated buccal mucosal cells. Mutat.Res 8-8-2004;562(1-2):27-38. View abstract.
Wyatt, T. A. Betel nut chewing and selected psychophysiological variables. Psychol.Rep. 1996;79(2):451-463. View abstract.
Yang, Y. H., Chen, C. H., Chang, J. S., Lin, C. C., Cheng, T. C., and Shieh, T. Y. Incidence rates of oral cancer and oral pre-cancerous lesions in a 6-year follow-up study of a Taiwanese aboriginal community. J Oral Pathol Med 2005;34(10):596-601. View abstract.
Yang, Y. H., Lee, H. Y., Tung, S., and Shieh, T. Y. Epidemiological survey of oral submucous fibrosis and leukoplakia in aborigines of Taiwan. J Oral Pathol Med 2001;30(4):213-219. View abstract.
Yen, A. M., Chen, L. S., Chiu, Y. H., Boucher, B. J., and Chen, T. H. A prospective community-population-registry based cohort study of the association between betel-quid chewing and cardiovascular disease in men in Taiwan (KCIS no. 19). Am J Clin Nutr 2008;87(1):70-78. View abstract.
Yen, A. M., Chiu, Y. H., Chen, L. S., Wu, H. M., Huang, C. C., Boucher, B. J., and Chen, T. H. A population-based study of the association between betel-quid chewing and the metabolic syndrome in men. Am J Clin Nutr 2006;83(5):1153-1160. View abstract.
Yen, C. F. and Chong, M. Y. Comorbid psychiatric disorders, sex, and methamphetamine use in adolescents: a case-control study. Compr.Psychiatry 2006;47(3):215-220. View abstract.
Yin, X. M., Peng, J. Y., and Gao, Y. J. [Clinical study on the relationship between tooth abrasion and the habits of chewing betel nut]. Hunan.Yi.Ke.Da.Xue.Xue.Bao. 2003;28(2):171-173. View abstract.
Cox SC, Walker DM. Oral submucous fibrosis. A review. Aust Dent J 1996;41:294-9. View abstract.
Gilani, A. H., Ghayur, M. N., Saify, Z. S., Ahmed, S. P., Choudhary, M. I., and Khalid, A. Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut. Life Sci 10-1-2004;75(20):2377-2389. View abstract.
Gupta PC, Sinor PN, Bhonsle RB, et al. Oral submucous fibrosis in India: a new epidemic? Natl Med J India 1998;11:113-6. View abstract.
Lopez-Vilchez, M. A., Seidel, V., Farre, M., Garcia-Algar, O., Pichini, S., and Mur, A. Areca-nut abuse and neonatal withdrawal syndrome. Pediatrics 2006;117(1):e129-e131. View abstract.
Sullivan RJ, Allen JS, Otto C, et al. Effects of chewing betel nut (Areca catechu) on the symptoms of people with schizophrenia in Palau, Micronesia. Br J Psychiatry 2000;177:174-8. View abstract.
Trivedy C, Warnakulasuriya S, Peters TJ. Areca nuts can have deleterious effects. BMJ 1999;318:1287. View abstract.
VanWyk CW. Oral submucous fibrosis. The South African experience. Indian J Dent Res 1997;8:39-45. View abstract.