Black Tang, Bladder Fucus, Bladder Wrack, Bladderwrack, Blasentang, Cutweed, Dyer's Fucus, Fucus Vésiculeux, Goémon, Kelp, Kelpware, Kelp-Ware, Ocean Kelp, Quercus Marina, Red Fucus, Rockwrack, Sea Kelp, Sea Oak, Seawrack, Varech, Varech Vésiculeux.
Fucus vesiculosus is a type of brown seaweed. People use the whole plant to make medicine.
People use Fucus vesiculosus for conditions such as thyroid disorders, iodine deficiency, obesity, and many others, but there is no good scientific evidence to support these uses. Using Fucus vesiculosus can also be unsafe.
Don't confuse Fucus vesiculosus with bladderwort.
How does work?
Fucus vesiculosus contains varying amounts of iodine. The iodine might help prevent or treat some thyroid disorders. Fucus vesiculosus also might have antidiabetic effects, and may affect hormone levels. But more information is needed.
Insufficient Evidence to Rate Effectiveness for...
- Obesity. Early research suggests that taking Fucus vesiculosus along with lecithin and vitamins doesn't help people lose weight.
- Achy joints (rheumatism).
- Arthritis.
- "Blood cleansing".
- Constipation.
- Digestive problems.
- "Hardening of the arteries" (arteriosclerosis).
- Iodine deficiency.
- Thyroid problems, including an over-sized thyroid gland (goiter).
- Other conditions.
QUESTION
Next to red peppers, you can get the most vitamin C from ________________. See AnswerFucus vesiculosus is POSSIBLY SAFE when applied to the skin. It is POSSIBLY UNSAFE when taken by mouth. It may contain high concentrations of iodine. Large amounts of iodine can cause or worsen some thyroid problems. It may also contain heavy metals, which can cause heavy metal poisoning. Treatment of thyroid problems should not be attempted without medical supervision.
Pregnancy and breast-feeding: Fucus vesiculosus is POSSIBLY UNSAFE during pregnancy and breast-feeding. Don't use it.
Bleeding disorders: Fucus vesiculosus might slow blood clotting. In theory, Fucus vesiculosus might increase the risk of bruising or bleeding in people with bleeding disorders.
Diabetes: Fucus vesiculosus may affect blood sugar levels. If you have diabetes and take medications to lower your blood sugar, adding Fucus vesiculosus might make your blood sugar drop too low. Monitor your blood sugar carefully.
Infertility: Preliminary research suggests that taking Fucus vesiculosus might make it harder for women to get pregnant.
Iodine allergy: Fucus vesiculosus contains significant amounts of iodine, which could cause an allergic reaction in sensitive people. Don't use it.
Surgery: Fucus vesiculosus might slow blood clotting. There is a concern that it might cause extra bleeding during and after surgery. Stop taking Fucus vesiculosus at least 2 weeks before surgery.
Thyroid problems known as hyperthyroidism (too much thyroid hormone), or hypothyroidism (too little thyroid hormone): Fucus vesiculosus contains significant amounts of iodine, which might make hyperthyroidism and hypothyroidism worse. Don't use it.
LithiumInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Fucus vesiculosus can contain significant amounts of iodine. Iodine can affect the thyroid. Lithium can also affect the thyroid. Taking iodine along with lithium might increase the thyroid too much.
Medications for an overactive thyroid (Antithyroid drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Fucus vesiculosus can contain significant amounts of iodine. Iodine can affect the thyroid. Taking iodine along with medications for an overactive thyroid might decrease the thyroid too much, or may affect how antithyroid medications work. Do not take Fucus vesiculosus if you are taking medications for an overactive thyroid.
Some of these medications include methenamine mandelate (Methimazole), methimazole (Tapazole), potassium iodide (Thyro-Block), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Fucus vesiculosus might slow blood clotting. Taking Fucus vesiculosus along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
The appropriate dose of Fucus vesiculosus depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for Fucus vesiculosus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Abidov, M., Ramazanov, Z., Seifulla, R., and Grachev, S. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes.Metab 2010;12(1):72-81. View abstract.
Alraei, RG. Herbal and Dietary Supplements for Weight Loss. Topics in Clinical Nutrition. 2010;25(2):136-150.
Araya, N., Takahashi, K., Sato, T., Nakamura, T., Sawa, C., Hasegawa, D., Ando, H., Aratani, S., Yagishita, N., Fujii, R., Oka, H., Nishioka, K., Nakajima, T., Mori, N., and Yamano, Y. Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease. Antivir.Ther. 2011;16(1):89-98. View abstract.
Arbaizar, B. and Llorca, J. [Fucus vesiculosus induced hyperthyroidism in a patient undergoing concomitant treatment with lithium]. Actas Esp.Psiquiatr. 2011;39(6):401-403. View abstract.
Bell, J., Duhon, S., and Doctor, V. M. The effect of fucoidan, heparin and cyanogen bromide-fibrinogen on the activation of human glutamic-plasminogen by tissue plasminogen activator. Blood Coagul.Fibrinolysis 2003;14(3):229-234. View abstract.
Bezpalov, V. G., Barash, N. I., Ivanova, O. A., Semenov, I. I., Aleksandrov, V. A., and Semiglazov, V. F. [Investigation of the drug "Mamoclam" for the treatment of patients with fibroadenomatosis of the breast]. Vopr.Onkol. 2005;51(2):236-241. View abstract.
Bradley MD, Nelson A Petticrew M Cullum N Sheldon T. Dressing for pressure sores. Cochrane Library 2011;0:0.
Burack, J. H., Cohen, M. R., Hahn, J. A., and Abrams, D. I. Pilot randomized controlled trial of Chinese herbal treatment for HIV- associated symptoms. J Acquir.Immune.Defic.Syndr.Hum.Retrovirol. 8-1-1996;12(4):386-393. View abstract.
Capitanio, B., Sinagra, J. L., Weller, R. B., Brown, C., and Berardesca, E. Randomized controlled study of a cosmetic treatment for mild acne. Clin.Exp.Dermatol. 2012;37(4):346-349. View abstract.
Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. View abstract.
Cho, H. B., Lee, H. H., Lee, O. H., Choi, H. S., Choi, J. S., and Lee, B. Y. Clinical and microbial evaluation of the effects on gingivitis of a mouth rinse containing an Enteromorpha linza extract. J.Med.Food 2011;14(12):1670-1676. View abstract.
Church FC, Meade JB, Treanor RE, and et al. Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin. J Biol Chem 2-25-1989;264(6):3618-3623. View abstract.
Colliec S, Fischer AM, Tapon-Bretaudiere J, and et al. Anticoagulant properties of a fucoidan fraction. Thromb Res 10-15-1991;64(2):143-154. View abstract.
Cooper, R., Dragar, C., Elliot, K., Fitton, J. H., Godwin, J., and Thompson, K. GFS, a preparation of Tasmanian Undaria pinnatifida is associated with healing and inhibition of reactivation of Herpes. BMC.Complement Altern.Med. 11-20-2002;2:11. View abstract.
Criado, M. T. and Ferreiros, C. M. Selective interaction of a Fucus vesiculosus lectin-like mucopolysaccharide with several Candida species. Ann Microbiol (Paris) 1983;134A(2):149-154. View abstract.
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., Grachev, A. A., Sanderson, C. J., Kelly, M., Rabinovich, G. A., Iacobelli, S., and Nifantiev, N. E. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 2007;17(5):541-552. View abstract.
Drnek, F., Prokes, B., and Rydlo, O. [Experiment in affecting cancer biologically with an intramuscular and local administration of the seaweed, Scenedesmus obliquus]. Cesk.Gynekol. 1981;46(6):463-465. View abstract.
Drozhzhina, V. A., Fedorov, IuA, Blokhin, V. P., Soboleva, T. I., and Kazakova, O. V. [The use of dental elixirs based on natural biologically active substances in the treatment and prevention of periodontal diseases]. Stomatologiia (Mosk) 1996;Spec No:52-53. View abstract.
Dumelod, B. D., Ramirez, R. P., Tiangson, C. L., Barrios, E. B., and Panlasigui, L. N. Carbohydrate availability of arroz caldo with lambda-carrageenan. Int.J.Food Sci.Nutr. 1999;50(4):283-289. View abstract.
Eliason, B. C. Transient hyperthyroidism in a patient taking dietary supplements containing kelp. J Am Board Fam.Pract. 1998;11(6):478-480. View abstract.
Ellouali M, Boisson-Vidal C, Durand P, and et al. Antitumor activity of low molecular weight fucans extracted from brown seaweed Ascophyllum nodosum. Anticancer Res 1993;13(6A):2011-2020. View abstract.
Ewart, S Girouard G. Tiller C. et al. Antidiabetic Activities of a Seaweed Extract. Diabetes. 2004;53(Supplement 2):A509.
Fluhr, J. W., Breternitz, M., Kowatzki, D., Bauer, A., Bossert, J., Elsner, P., and Hipler, U. C. Silver-loaded seaweed-based cellulosic fiber improves epidermal skin physiology in atopic dermatitis: safety assessment, mode of action and controlled, randomized single-blinded exploratory in vivo study. Exp.Dermatol. 2010;19(8):e9-15. View abstract.
Fowler, E. and Papen, J. C. Evaluation of an alginate dressing for pressure ulcers. Decubitus. 1991;4(3):47-8, 50, 52. View abstract.
Frestedt, J. L., Kuskowski, M. A., and Zenk, J. L. A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: a randomised, placebo controlled pilot study. Nutr.J. 2009;8:7. View abstract.
Gaigi, S., Elati, J., Ben, Osman A., and Beji, C. [Experimental study of the effects of seaweed in the treatment of obesity]. Tunis Med. 1996;74(5):241-243. View abstract.
Grauffel V, Kloareg B, Mabeau S, and et al. New natural polysaccharides with potent antithrombic activity: fucans from brown algae. Biomaterials 1989;10(6):363-368. View abstract.
Hall, A. C., Fairclough, A. C., Mahadevan, K., and Paxman, J. R. Ascophyllum nodosum enriched bread reduces subsequent energy intake with no effect on post-prandial glucose and cholesterol in healthy, overweight males. A pilot study. Appetite 2012;58(1):379-386. View abstract.
Irhimeh, M. R., Fitton, J. H., and Lowenthal, R. M. Pilot clinical study to evaluate the anticoagulant activity of fucoidan. Blood Coagul.Fibrinolysis 2009;20(7):607-610. View abstract.
Jeukendrup, A. E. and Randell, R. Fat burners: nutrition supplements that increase fat metabolism. Obes.Rev. 2011;12(10):841-851. View abstract.
Kang, Y. M., Lee, B. J., Kim, J. I., Nam, B. H., Cha, J. Y., Kim, Y. M., Ahn, C. B., Choi, J. S., Choi, I. S., and Je, J. Y. Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of gamma-GT: A randomized, double-blind, and placebo-controlled clinical study. Food Chem.Toxicol. 2012;50(3-4):1166-1169. View abstract.
Lamela M, Anca J, Villar R, and et al. Hypoglycemic activity of several seaweed extracts. J.Ethnopharmacol. 1989;27(1-2):35-43. View abstract.
Le Tutour B, Benslimane F, Gouleau MP, and et al. Antioxidant and pro-oxidant activities of the brown algae, Laminaria digitata, Himanthalia elongata, Fucus vesiculosus, Fucus serratus and Ascophyllum nodosum. J Applied Phycology 1998;10(2):121-129.
Lindsey, H. Use of Botanicals for Cancer: Systematic Research Required to Determine Role. Oncology Times. 2005;27(6):52-55.
Lis-Balchin, M. Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite. Phytother.Res. 1999;13(7):627-629. View abstract.
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., and Miyashita, K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int.J.Mol.Med. 2006;18(1):147-152. View abstract.
Marais, D., Gawarecki, D., Allan, B., Ahmed, K., Altini, L., Cassim, N., Gopolang, F., Hoffman, M., Ramjee, G., and Williamson, A. L. The effectiveness of Carraguard, a vaginal microbicide, in protecting women against high-risk human papillomavirus infection. Antivir.Ther. 2011;16(8):1219-1226. View abstract.
Martyn-St James M., O'Meara S. Foam dressings for venous leg ulcers. Cochrane Library. 2012;0:0.
Maruyama H, Nakajima J, and Yamamoto I. A study on the anticoagulant and fibrinolytic activities of a crude fucoidan from the edible brown seaweed Laminaria religiosa, with special reference to its inhibitory effect on the growth of sarcoma-180 ascites cells subcutaneously implanted into mice. Kitasato Arch Exp Med 1987;60(3):105-121. View abstract.
Michikawa, T., Inoue, M., Shimazu, T., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., and Tsugane, S. Seaweed consumption and the risk of thyroid cancer in women: the Japan Public Health Center-based Prospective Study. Eur.J.Cancer Prev. 2012;21(3):254-260. View abstract.
Misurcova, L., Machu, L., and Orsavova, J. Seaweed minerals as nutraceuticals. Adv.Food Nutr.Res. 2011;64:371-390. View abstract.
Miyashita, K., Nishikawa, S., Beppu, F., Tsukui, T., Abe, M., and Hosokawa, M. The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds. J.Sci.Food Agric. 2011;91(7):1166-1174. View abstract.
Monego, E. T., Peixoto, Mdo R., Jardim, P. C., Sousa, A. L., Braga, V. L., and Moura, M. F. [Different therapies in the treatment of obesity in hypertensive patients]. Arq Bras.Cardiol. 1996;66(6):343-347. View abstract.
Nelson, E. A. and Bradley, M. D. Dressings and topical agents for arterial leg ulcers. Cochrane.Database.Syst.Rev. 2007;(1):CD001836. View abstract.
Obiero, J., Mwethera, P. G., and Wiysonge, C. S. Topical microbicides for prevention of sexually transmitted infections. Cochrane.Database.Syst.Rev. 2012;6:CD007961. View abstract.
Odunsi, S. T., Vazquez-Roque, M. I., Camilleri, M., Papathanasopoulos, A., Clark, M. M., Wodrich, L., Lempke, M., McKinzie, S., Ryks, M., Burton, D., and Zinsmeister, A. R. Effect of alginate on satiation, appetite, gastric function, and selected gut satiety hormones in overweight and obesity. Obesity.(Silver.Spring) 2010;18(8):1579-1584. View abstract.
Oh, J. K., Shin, Y. O., Yoon, J. H., Kim, S. H., Shin, H. C., and Hwang, H. J. Effect of supplementation with Ecklonia cava polyphenol on endurance performance of college students. Int.J.Sport Nutr.Exerc.Metab 2010;20(1):72-79. View abstract.
Palfreyman, S. J., Nelson, E. A., Lochiel, R., and Michaels, J. A. Dressings for healing venous leg ulcers. Cochrane.Database.Syst.Rev. 2006;(3):CD001103. View abstract.
Pangestuti, R. and Kim, S. K. Neuroprotective effects of marine algae. Mar.Drugs 2011;9(5):803-818. View abstract.
Paradis, M. E., Couture, P., and Lamarche, B. A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Appl.Physiol Nutr.Metab 2011;36(6):913-919. View abstract.
Park, K. Y., Jang, W. S., Yang, G. W., Rho, Y. H., Kim, B. J., Mun, S. K., Kim, C. W., and Kim, M. N. A pilot study of silver-loaded cellulose fabric with incorporated seaweed for the treatment of atopic dermatitis. Clin.Exp.Dermatol. 2012;37(5):512-515. View abstract.
Paxman, J. R., Richardson, J. C., Dettmar, P. W., and Corfe, B. M. Daily ingestion of alginate reduces energy intake in free-living subjects. Appetite 2008;51(3):713-719. View abstract.
Riou D, Colliec-Jouault S, Pinczon du Sel D, and et al. Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Res 1996;16(3A):1213-1218. View abstract.
Rowe, B. R., Bain, S. C., Pizzey, M., and Barnett, A. H. Rapid healing of ulcerated necrobiosis lipoidica with optimum glycaemic control and seaweed-based dressings. Br.J.Dermatol. 1991;125(6):603-604. View abstract.
Rudichenko, E. V., Gvozdenko, T. A., and Antoniuk, M. V. [Impact of dietotherapy with enterosorbent of marine origin on the indices of mineral and lipid metabolism for patients suffering from kidney diseases]. Vopr.Pitan. 2005;74(4):33-35. View abstract.
Sakata, T. A very-low-calorie conventional Japanese diet: its implications for prevention of obesity. Obes.Res. 1995;3 Suppl 2:233s-239s. View abstract.
Schreuder SM, Vermeulen H Qureshi MA Ubbink DT. Dressings and topical agents for donor sites of split-thickness skin grafts. JOURNAL 2009;0:0.
Shilo, S. and Hirsch, H. J. Iodine-induced hyperthyroidism in a patient with a normal thyroid gland. Postgrad Med J 1986;62(729):661-662. View abstract.
Shin, H. C., Kim, S. H., Park, Y., Lee, B. H., and Hwang, H. J. Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial. Phytother.Res. 2012;26(3):363-368. View abstract.
Soeda S, Sakaguchi S, Shimeno H, and et al. Fibrinolytic and anticoagulant activities of highly sulfated fucoidan. Biochem Pharmacol 4-15-1992;43(8):1853-1858. View abstract.
SPRINGER, G. F., WURZEL, H. A., and Mcneal, G. M. et al. Isolation of anticoagulant fractions from crude fucoidin. Proc.Soc.Exp.Biol.Med 1957;94(2):404-409. View abstract.
Teas, J., Baldeon, M. E., Chiriboga, D. E., Davis, J. R., Sarries, A. J., and Braverman, L. E. Could dietary seaweed reverse the metabolic syndrome? Asia Pac.J.Clin.Nutr. 2009;18(2):145-154. View abstract.
Teas, J., Braverman, L. E., Kurzer, M. S., Pino, S., Hurley, T. G., and Hebert, J. R. Seaweed and soy: companion foods in Asian cuisine and their effects on thyroid function in American women. J Med Food 2007;10(1):90-100. View abstract.
Vasilevskaia, L. S., Pogozheva, A. V., Derbeneva, S. A., Zorin, S. N., Buchanova, A. V., Abramova, L. S., Petrukhanova, A. V., Gmoshinskii, I. V., and Mazo, V. K. [Clinical efficiency of using laminaria jam enriched with selenium]. Vopr.Pitan. 2009;78(1):79-83. View abstract.
Vermeulen, H., Ubbink, D., Goossens, A., de, Vos R., and Legemate, D. Dressings and topical agents for surgical wounds healing by secondary intention. Cochrane.Database.Syst.Rev. 2004;(2):CD003554. View abstract.
Wasiak, J., Cleland, H., and Campbell, F. Dressings for superficial and partial thickness burns. Cochrane.Database.Syst.Rev. 2008;(4):CD002106. View abstract.
Yamamoto I, Nagumo T, Fujihara M, and et al. Antitumor effect of seaweeds. II. Fractionation and partial characterization of the polysaccharide with antitumor activity from Sargassum fulvellum. Jpn.J Exp Med 1977;47(3):133-140. View abstract.
Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. View abstract.
Baba M, Snoeck R, Pauwels R, de Clercq E. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antimicrob Agents Chemother 1988;32:1742-5. View abstract.
Baker DH. Iodine toxicity and its amelioration. Exp Biol Med (Maywood) 2004;229:473-8. View abstract.
Beress A, Wassermann O, Tahhan S, et al. A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus. J Nat Prod 1993;56:478-88. View abstract.
Bjorvell H, Rössner S. Long-term effects of commonly available weight reducing programmes in Sweden. Int J Obes 1987;11:67-71. . View abstract.
Conz PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: a nephrotoxic alga? Nephrol Dial Transplant 1998;13:526-7. View abstract.
Criado MT, Ferreiros CM. Toxicity of an algal mucopolysaccharide for Escherichia coli and Neisseria meningitidis strains. Rev Esp Fisiol 1984;40:227-30. View abstract.
Durig J, Bruhn T, Zurborn KH, et al. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 1997;85:479-91. View abstract.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
Frestedt, J. L., Walsh, M., Kuskowski, M. A., and Zenk, J. L. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial. Nutr J 2008;7:9. View abstract.
Fujimura T, Tsukahara K, Moriwaki S, et al. Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties. J Cosmet Sci 2002;53:1-9. View abstract.
Koyanagi S, Tanigawa N, Nakagawa H, et al. Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol 2003;65:173-9. View abstract.
O'Leary R, Rerek M, Wood EJ. Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair. Biol Pharm Bull 2004;27:266-70. View abstract.
Ohye H, Fukata S, Kanoh M, et al. Thyrotoxicosis caused by weight-reducing herbal medicines. Arch Intern Med 2005;165:831-4. View abstract.
Okamura K, Inoue K, Omae T. A case of Hashimoto's thyroiditis with thyroid immunological abnormality manifested after habitual ingestion of seaweed. Acta Endocrinol (Copenh) 1978;88:703-12. View abstract.
Patankar MS, Oehninger S, Barnett T, et al. A revised structure for fucoidan may explain some of its biological activities. J Biol Chem 1993;268:21770-6. View abstract.
Phaneuf D, Cote I, Dumas P, et al. Evaluation of the contamination of marine algae (Seaweed) from the St. Lawrence River and likely to be consumed by humans. Environ Res 1999;80:S175-S182. View abstract.
Pye KG, Kelsey SM, House IM, et al. Severe dyserythropoeisis and autoimmune thrombocytopenia associated with ingestion of kelp supplement. Lancet 1992;339:1540. View abstract.
Ruperez P, Ahrazem O, Leal JA. Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem 2002;50:840-5. View abstract.
Skibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC Complement Altern Med 2004;4:10. View abstract.
Torn K, Krause-Jensen D, Martin G. Present and past depth distribution of bladderwrack (Fucus vesiculosus) in the Baltic Sea. Aquatic Botany 2006;84:53-62.
US Department of Health and Human Services, Public Health Service. Agency for Toxic Substances and Disease Registry. Toxicological profile for strontium. April 2004. Available at: www.atsdr.cdc.gov/toxprofiles/tp159.pdf. (Accessed 8 August 2006).
Wikström SA, Kautsky L. Structure and diversity of invertebrate communities in the presence and absence of canopy-forming Fucus vesiculosus in the Baltic Sea. Estuarine Coastal Shelf Sci 2007;72:168-176.