Atomic Number 50, Estanho, Estaño, Etain, Latta, Sn, Stannum, Tenn, Zinn.
Tin (Sn) is a metal. It can exist by itself as a pure compound, or as part of inorganic or organic compounds. Inorganic tin compounds form when tin combines with other elements such as chloride, fluoride, sulfur, or oxygen. Organic tin compounds form when tin binds to carbon.
People take tin by mouth for cancer.
People apply tin to the skin for bad breath, dental cavities, sensitive teeth, gingivitis, plaque, and hair loss.
Tin is used to make plastics, pesticides, paints, wood preservatives, and rodent repellants in manufacturing.
How does work?
Tin fluoride seems to prevent bacteria from forming, which might prevent plaque and cavities. Tin compounds also seem to prevent the nerves around the teeth from being stimulated, which can prevent tooth sensitivity.
Insufficient Evidence to Rate Effectiveness for...
- Sensitive teeth. Research suggests that applying a gel containing tin fluoride to the teeth might reduce tooth sensitivity. However, it does not seem to be as effective as a sodium fluoride solution.
- Dental plaque. Some research shows that using a paste containing tin fluoride prevents plaque from forming better than some other toothpastes. However, there are inconsistencies with this research.
- Gingivitis. Some evidence suggests that using a paste containing tin fluoride reduces gingivitis better than some other toothpastes. However, there are inconsistencies with this research.
- Cancer.
- Bad breath.
- Dental cavities.
- Hair loss.
- Other conditions.

SLIDESHOW
Vitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowThere isn't enough reliable information available about tin to know if it is safe.
Some forms of tin (inorganic tin) might cause stomach problems, including diarrhea, stomach pain, or nausea when taken by mouth in large amounts. Other types of tin (organic tin) might cause headache, dizziness, seizures, vision problems, confusion, and possibly death when taken by mouth or when inhaled.
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking tin if you are pregnant or breast-feeding. Stay on the safe side and avoid use.The appropriate dose of tin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for tin (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Nielsen, F. H. How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr 1996;126(9 Suppl):2377S-2385S. View abstract.
Akagi, R., Takahashi, T., and Sassa, S. Cytoprotective effects of heme oxygenase in acute renal failure. Contrib Nephrol 2005;148:70-85. View abstract.
Arakawa, Y. [Biological activity of tin and immunity]. Sangyo Eiseigaku Zasshi 1997;39(1):1-20. View abstract.
Aschner, M., Gannon, M., and Kimelberg, H. K. Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium, L-glutamate and D-aspartate. Brain Res 1992;582(2):181-185. View abstract.
Blunden, S. and Wallace, T. Tin in canned food: a review and understanding of occurrence and effect. Food Chem Toxicol 2003;41(12):1651-1662. View abstract.
Cardarelli, N. Tin and the thymus gland: a review. Thymus 1990;15(4):223-231. View abstract.
Caussy, D., Gochfeld, M., Gurzau, E., Neagu, C., and Ruedel, H. Lessons from case studies of metals: investigating exposure, bioavailability, and risk. Ecotoxicol Environ Saf 2003;56(1):45-51. View abstract.
Clarkson, T. W. Metal toxicity in the central nervous system. Environ Health Perspect 1987;75:59-64. View abstract.
Greger, J. L. and Johnson, M. A. Effect of dietary tin on zinc. Copper and iron utilization in rats. Food Cosmet Toxicol 1981;19(2):163-166. View abstract.
Herczegh, A., Gombik, A., Rost, M., Wierzbicka, M., and Banoczy, J. [Study of the effectiveness of amine fluoride and stannous fluoride containing toothpaste and mouthwash]. Fogorv Sz 1991;84(6-7):181-184. View abstract.
Hirner, A. V. and Rettenmeier, A. W. Methylated metal(loid) species in humans. Met Ions Life Sci 2010;7:465-521. View abstract.
Jackson-Rosario, S. E. and Self, W. T. Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery. Metallomics 2010;2(2):112-116. View abstract.
Johnson, M. A., Baier, M. J., and Greger, J. L. Effects of dietary tin on zinc, copper, iron, manganese, and magnesium metabolism of adult males. Am J Clin Nutr 1982;35:1332-1338.
Kimbrough, R. D. Toxicity and health effects of selected organotin compounds: a review. Environ Health Perspect 1976;14:51-56. View abstract.
Krigman, M. R. and Silverman, A. P. General toxicology of tin and its organic compounds. Neurotoxicology 1984;5(2):129-139. View abstract.
Miller, S., Truong, T., Heu, R., Stranick, M., Bouchard, D., and Gaffar, A. Recent advances in stannous fluoride technology: antibacterial efficacy and mechanism of action towards hypersensitivity. Int Dent J 1994;44(1 Suppl 1):83-98. View abstract.
Mori, Y., Iesato, K., Ueda, S., Mori, T., Iwasaki, I., Ohnishi, K., Seino, Y., Wakashin, Y., Wakashin, M., and Okuda, K. Renal tubular disturbances induced by tributyl-tin oxide in guinea pigs: a secondary Fanconi syndrome. Clin Nephrol 1984;21(2):118-125. View abstract.
Paraskevas, S. and van der Weijden, G. A. A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006;33(1):1-13. View abstract.
Rolla, G. and Ellingsen, J. E. Clinical effects and possible mechanisms of action of stannous fluoride. Int Dent J 1994;44(1 Suppl 1):99-105. View abstract.
Rudel, H. Case study: bioavailability of tin and tin compounds. Ecotoxicol Environ Saf 2003;56(1):180-189. View abstract.
Sampson, C. B. Complications and difficulties in radiolabelling blood cells: a review. Nucl Med Commun 1996;17(8):648-658. View abstract.
Sensabaugh, C. and Sagel, M. E. Stannous fluoride dentifrice with sodium hexametaphosphate: review of laboratory, clinical and practice-based data. J Dent Hyg 2009;83(2):70-78. View abstract.
Sherman, L. R., Masters, J., Peterson, R., and Levine, S. Tin concentration in the thymus glands of rats and mice and its relation to the involution of the gland. J Anal Toxicol 1986;10(1):6-9. View abstract.
Sjostrom, S. and Kalfas, S. Tissue necrosis after subgingival irrigation with fluoride solution. J Clin Periodontol 1999;26(4):257-260. View abstract.
Thrash, W. J., Dodds, M. W., and Jones, D. L. The effect of stannous fluoride on dentinal hypersensitivity. Int Dent J 1994;44(1 Suppl 1):107-118. View abstract.
US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
White, D. J. Reactivity of fluoride dentifrices with artificial caries. I. Effects on early lesions: F uptake, surface hardening and remineralization. Caries Res 1987;21(2):126-140. View abstract.
White, D. J. Reactivity of fluoride dentifrices with artificial caries. II. Effects on subsurface lesions: F uptake, F distribution, surface hardening and remineralization. Caries Res 1988;22(1):27-36. View abstract.
Winship, K. A. Toxicity of tin and its compounds. Adverse Drug React Acute Poisoning Rev 1988;7(1):19-38. View abstract.