Trumpet Satinash: Health Benefits, Side Effects, Uses, Dose & Precautions

Other Name(s):

Syzygium claviflorum, Trompeta satinash.

Overview

Trumpet satinash is a shrub that contains betulinic acid. Betulinic acid is believed to have possible benefits in humans.

People take trumpet satinash by mouth for cancer and HIV/AIDS.

How does work?

Trumpet satinash contains betulinic acid. Betulinic acid seems to have positive effects in humans, including antiparasitic, anticancer, anti-inflammatory, anti-obesity, antiviral, and fertility-boosting effects.

Uses

Insufficient Evidence to Rate Effectiveness for...

Cancer.
HIV/AIDS.
Other conditions.

More evidence is needed to rate trumpet satinash for these uses.

Side Effects

There isn't enough reliable information available about trumpet satinash to know if it is safe or what the side effects might be.

Precautions

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking trumpet satinash if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Dosing

The appropriate dose of trumpet satinash depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for trumpet satinash (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

References

Kashiwada, Y., Wang, H. K., Nagao, T., Kitanaka, S., Yasuda, I., Fujioka, T., Yamagishi, T., Cosentino, L. M., Kozuka, M., Okabe, H., Ikeshiro, Y., Hu, C. Q., Yeh, E., and Lee, K. H. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. J Nat Prod 1998;61(9):1090-1095. View abstract.

Basu, S., Ma, R., Boyle, P. J., Mikulla, B., Bradley, M., Smith, B., Basu, M., and Banerjee, S. Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside. Glycoconj J 2004;20(9):563-577. View abstract.

Bringmann, G., Saeb, W., Assi, L. A., Francois, G., Sankara Narayanan, A. S., Peters, K., and Peters, E. M. Betulinic acid: isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester. Planta Med 1997;63(3):255-257. View abstract.

Chen, Z., Wu, Q., Chen, Y., and He, J. Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism. J Huazhong Univ Sci Technolog Med Sci 2008;28(6):634-638. View abstract.

Chintharlapalli, S., Papineni, S., Ramaiah, S. K., and Safe, S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res 2007;67(6):2816-2823. View abstract.

Chung, M. Y., Rho, M. C., Lee, S. W., Park, H. R., Kim, K., Lee, I. A., Kim, D. H., Jeune, K. H., Lee, H. S., and Kim, Y. K. Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta. Planta Med 2006;72(3):267-269. View abstract.

Dathe, S., Paasch, U., Grunewald, S., and Glander, H. J. [Mitochondrial damage in human sperm caused by the antineoplastic agent betulinic acid]. Hautarzt 2005;56(8):768-772. View abstract.

de Sa, M. S., Costa, J. F., Krettli, A. U., Zalis, M. G., Maia, G. L., Sette, I. M., Camara, Cde A., Filho, J. M., Giulietti-Harley, A. M., Ribeiro Dos, Santos R., and Soares, M. B. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Res 2009;105(1):275-279. View abstract.

Ehrhardt, H., Fulda, S., Fuhrer, M., Debatin, K. M., and Jeremias, I. Betulinic acid-induced apoptosis in leukemia cells. Leukemia 2004;18(8):1406-1412. View abstract.

Eksioglu-Demiralp, E., Kardas, E. R., Ozgul, S., Yagci, T., Bilgin, H., Sehirli, O., Ercan, F., and Sener, G. Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis. Phytother Res 2010;24(3):325-332. View abstract.

Enwerem, N. M., Okogun, J. I., Wambebe, C. O., Okorie, D. A., and Akah, P. A. Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid. Phytomedicine 2001;8(2):112-114. View abstract.

Fujioka, T., Kashiwada, Y., Kilkuskie, R. E., Cosentino, L. M., Ballas, L. M., Jiang, J. B., Janzen, W. P., Chen, I. S., and Lee, K. H. Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 1994;57(2):243-247. View abstract.

Fulda, S. and Debatin, K. M. Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. Med Pediatr Oncol 2000;35(6):616-618. View abstract.

Fulda, S. and Debatin, K. M. Sensitization for anticancer drug-induced apoptosis by betulinic Acid. Neoplasia 2005;7(2):162-170. View abstract.

Fulda, S., Friesen, C., Los, M., Scaffidi, C., Mier, W., Benedict, M., Nunez, G., Krammer, P. H., Peter, M. E., and Debatin, K. M. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997;57(21):4956-4964. View abstract.

Fulda, S., Jeremias, I., and Debatin, K. M. Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells. Oncogene 2004;23(46):7611-7620. View abstract.

Fulda, S., Scaffidi, C., Susin, S. A., Krammer, P. H., Kroemer, G., Peter, M. E., and Debatin, K. M. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 1998;273(51):33942-33948. View abstract.

Ganguly, A., Das, B., Roy, A., Sen, N., Dasgupta, S. B., Mukhopadhayay, S., and Majumder, H. K. Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer Res 2007;67(24):11848-11858. View abstract.

Huang, L., Ho, P., and Chen, C. H. Activation and inhibition of the proteasome by betulinic acid and its derivatives. FEBS Lett 2007;581(25):4955-4959. View abstract.

Karpova, M. B., Sanmun, D., Henter, J. I., Smirnov, A. F., and Fadeel, B. Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma-derived B-cell lines. Int J Cancer 2006;118(1):246-252. View abstract.

Kasperczyk, H., La Ferla-Bruhl, K., Westhoff, M. A., Behrend, L., Zwacka, R. M., Debatin, K. M., and Fulda, S. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene 2005;24(46):6945-6956. View abstract.

Kessler, J. H., Mullauer, F. B., de Roo, G. M., and Medema, J. P. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett 2007;251(1):132-145. View abstract.

Kwon, H. J., Shim, J. S., Kim, J. H., Cho, H. Y., Yum, Y. N., Kim, S. H., and Yu, J. Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn J Cancer Res 2002;93(4):417-425. View abstract.

Liu, W. K., Ho, J. C., Cheung, F. W., Liu, B. P., Ye, W. C., and Che, C. T. Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. Eur J Pharmacol 2004;498(1-3):71-78. View abstract.

Melzig, M. F. and Bormann, H. Betulinic acid inhibits aminopeptidase N activity. Planta Med 1998;64(7):655-657. View abstract.

Mullauer, F. B., Kessler, J. H., and Medema, J. P. Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis 2009;14(2):191-202. View abstract.

Nyasse, B., Nono, J. J., Nganso, Y., Ngantchou, I., and Schneider, B. Uapaca genus (Euphorbiaceae), a good source of betulinic acid. Fitoterapia 2009;80(1):32-34. View abstract.

Poon, K. H., Zhang, J., Wang, C., Tse, A. K., Wan, C. K., and Fong, W. F. Betulinic acid enhances 1alpha,25-dihydroxyvitamin D3-induced differentiation in human HL-60 promyelocytic leukemia cells. Anticancer Drugs 2004;15(6):619-624. View abstract.

Qiu, L., Wang, Q., Di, W., Jiang, Q., Schefeller, E., Derby, S., Wanebo, H., Yan, B., and Wan, Y. Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. Int J Oncol 2005;27(3):823-830. View abstract.

Rabi, T., Shukla, S., and Gupta, S. Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells. Mol Carcinog 2008;47(12):964-973. View abstract.

Raghuvar Gopal, D. V., Narkar, A. A., Badrinath, Y., Mishra, K. P., and Joshi, D. S. Protection of Ewing's sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by alpha-DL-tocopherol. Toxicol Lett 2004;153(2):201-212. View abstract.

Rieber, M. and Rieber, M. S. Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status. Int J Cancer 2006;118(5):1135-1143. View abstract.

Rieber, M. and Strasberg Rieber, M. Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma. DNA Cell Biol 1998;17(5):399-406. View abstract.

Rzeski, W., Stepulak, A., Szymanski, M., Sifringer, M., Kaczor, J., Wejksza, K., Zdzisinska, B., and Kandefer-Szerszen, M. Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Naunyn Schmiedebergs Arch Pharmacol 2006;374(1):11-20. View abstract.

Selzer, E., Pimentel, E., Wacheck, V., Schlegel, W., Pehamberger, H., Jansen, B., and Kodym, R. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. J Invest Dermatol 2000;114(5):935-940. View abstract.

Steele, J. C., Warhurst, D. C., Kirby, G. C., and Simmonds, M. S. In vitro and in vivo evaluation of betulinic acid as an antimalarial. Phytother Res 1999;13(2):115-119. View abstract.

Szuster-Ciesielska, A. and Kandefer-Szerszen, M. Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells. Pharmacol Rep 2005;57(5):588-595. View abstract.

Tan, Y., Yu, R., and Pezzuto, J. M. Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin Cancer Res 2003;9(7):2866-2875. View abstract.

Thurnher, D., Turhani, D., Pelzmann, M., Wannemacher, B., Knerer, B., Formanek, M., Wacheck, V., and Selzer, E. Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells. Head Neck 2003;25(9):732-740. View abstract.

Wick, W., Grimmel, C., Wagenknecht, B., Dichgans, J., and Weller, M. Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Exp Ther 1999;289(3):1306-1312. View abstract.

Yao, D., Li, H., Gou, Y., Zhang, H., Vlessidis, A. G., Zhou, H., Evmiridis, N. P., and Liu, Z. Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression. FEBS J 2009;276(9):2599-2614. View abstract.

Yasukawa, K., Takido, M., Matsumoto, T., Takeuchi, M., and Nakagawa, S. Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis. Oncology 1991;48(1):72-76. View abstract.

Yun, Y., Han, S., Park, E., Yim, D., Lee, S., Lee, C. K., Cho, K., and Kim, K. Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages. Arch Pharm Res 2003;26(12):1087-1095. View abstract.

Zdzisinska, B., Rzeski, W., Paduch, R., Szuster-Ciesielska, A., Kaczor, J., Wejksza, K., and Kandefer-Szerszen, M. Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures. Pol J Pharmacol 2003;55(2):235-238. View abstract.