Thiothixene

Thiothixene is a prescription medication used to treat the symptoms of Schizophrenia. 

• Thiothixene is available under the following different brand names: Navane

Common side effects of Thiothixene include:

• Dry mouth,
• Blurred vision,
• Nausea,
• Vomiting,
• Diarrhea,
• Constipation,
• Fast heartbeats,
• Restlessness,
• Breast swelling or discharge,
• Changes in weight or appetite, and
• Swelling in the hands or feet

Serious side effects of Thiothixene include:

• Hives,
• Difficulty breathing,
• Swelling of the face, lips, tongue, or throat,
• Uncontrolled muscle movements in the face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement),
• Stiffness in the neck,
• Tightness in the throat,
• Trouble swallowing,
• Seizure,
• Lightheadedness,
• Severe constipation,
• Fever,
• Chills,
• Mouth sores,
• Skin sores,
• Sore throat,
• Cough,
• Trouble breathing,
• Very stiff (rigid) muscles,
• High fever,
• Sweating,
• Confusion,
• Fast or uneven heartbeats, and
• Tremors

Rare side effects of Thiothixene include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;

Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;

Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Capsule

• 1 mg
• 2 mg
• 5 mg
• 10 mg

Schizophrenia

Adult dosage

• Mild-Moderate: Initial: 2 mg orally every 8 hours; may increase to 15 mg/day
• Severe: initial 5 mg orally every 12 hours
• Maintenance: 20-30 mg/day; no more than 60 mg/day orally divided every 8-12hour

Pediatric dosage

• Children below 12 years
  • Not recommended
• Children above 12 years
  • Mild-Moderate: Initial: 2 mg orally every 8 hours; may increase to 15 mg/day
  • Severe: initial 5 mg orally every 12 hours
  • Maintenance: 20-30 mg/day; no more than 60 mg/day orally divided every 8-12 hours

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Thiothixene has severe interactions with the following drug:
  • Amisulpride
• Thiothixene has serious interactions with at least 43 other drugs.
• Thiothixene has moderate interactions with at least 281 other drugs.
• Thiothixene has minor interactions with the following drugs:
  • Azithromycin
  • Brimonidine
  • Chaste berry
  • Chloroquine
  • Epinephrine
  • Epinephrine racemic
  • Ethanol
  • Eucalyptus
  • Sage

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Documented hypersensitivity
• Blood dyscrasias
• Coma
• Circulatory collapse
• CNS depression (including coma)
• Neuroleptic malignant syndrome (NMS)
• Poorly controlled seizure disorder
• Breastfeeding

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Flurbiprofen?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Flurbiprofen?”

Cautions

• Alcohol withdrawal, cardiovascular disease, glaucoma, BPH, history of seizure disorder, Parkinsonism, urinary retention, liver disease
• Potential cross-sensitivity between thioxanthenes & phenothiazine derivatives
• FDA Warning regarding off-label use for dementia in elderly
• Leukopenia/neutropenia and agranulocytosis were reported; possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell count (WBC) and a history of drug-induced leukopenia/neutropenia
• If history of clinically significant low WBC or drug-induced leukopenia/neutropenia, monitor complete blood count (CBC) frequently during the first few months of therapy; discontinue the drug at the first sign of a clinically significant decline below 1000/mm³ in WBC in absence of other causative factors and continue monitoring WBC until recovery.

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy.
• Neonates exposed to antipsychotic drugs during the 3rd trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery
• These complications vary in severity; in some cases, symptoms have been self-limited, while in other cases neonates have required intensive care unit support and prolonged hospitalization
• Lactation
  • May be excreted in breast milk; not advised