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Parnate Drug and Medication User Reviews on RxList

Parnate

USER REVIEWS

Comment from: 65-74 Transgender Caregiver Published: March 07

I have an anxiety disorder and been on Parnate since 1989. I do watch what I eat and have discovered that there are some foods that I can have in moderation, while there are others that I can't eat at all - it's very individual.This drug then, requires you to be very aware of your diet and to pay attention to what your body is telling you - which you should be doing anyway. So it's a little bit of work but have gotten very used to it. I've always had blood pressure that was on the low end of normal and that continues. My only frustration is that although I indicate on all medical forms that I am under Parnate treatment, a doctor may still prescribe another med for something else which is contraindicated. I am very careful and always check out the new drug, as well as anything OTC accordingly before I purchase it. The only down side for me is that I developed tinnitus as a result, and now wear hearing aids. The doctors cannot find any other cause for the hearing loss. As long as I keep taking the drug, I don't have any anxiety symptoms (which can be crippling) and it has allowed me to live a fairly normal life.

Comment from: Happy 45-54 Transgender 10 years or more Caregiver Published: November 10

I have been Parnate for 20 years and it is the only drug that has worked for my depression. It was literally a life changer. I tried many different drugs before I was prescribed Parnate. Some worked for a short time and then stopped working. Others didn't work or had terrible side effects. I do worry that the cost of this drug seems to be continually increasing. I cannot take the generic form as it does not work for me. As for the diet restrictions, I have NO problem leaving those things out of my diet in order to feel good mentally.

Comment from: Jan 55-64 Transgender 10 years or more Caregiver Published: August 16

I'm 63 female and been on parnate for 38 years, since I was 25. I still remember reading my first book and actually remembering it. At 63 it's been a long road on parnate and I still am today.

Comment from: Ann 45-54 Transgender 6 months to less than 1 year Caregiver Published: February 25

Parnate has saved my life. Before this drug, the other drugs worked for me for one day then stopped. I have met a lot of people that have had this experience with the newer drugs. I hate that it took so long for me to find a doctor to listen and believe what I said.Before Parnate my MDD was out of control. I never laughed or smiled about anything. This is the best I have felt in 14 years. I will continue to take it.

Comment from: Zeusko87 25-34 Transgender 1 to less than 2 years Caregiver Published: July 06

I just love this drug. Nardil is better for social anxiety but Parnate is much "user friendly". There are no many side effects beside constipation, fatique, trouble sleeping. But Parnate is also apetitte supresant. I take 60 mg of Parnate, benzo, lyrica and Modafnil and it helps with depression, anxiety ADD and fibromyalgia. SSSRIs are were not effective but Parnate is awesome.

Comment from: Zeusko87 25-34 Transgender 1 to less than 2 years Caregiver Published: July 06

I have tried every possible medication, but only Parnate together with a benzo and Lyrica works for my atypical, dopamine deficiency depression, social phobia and fibro pain.

Comment from: dad_in_texas 45-54 Transgender 1 to 6 months Caregiver Published: April 16

I’m a 52-yr old male, who struggled mightily with depression and anxiety and Parnate has been a game changer for me. Others didn’t work or one that did, Lexapro, pooped out after a period of time. I’d been miserable for several years. I still have my ups and downs from work issues, retirement anxieties, and other common life stressors, but I’m not paralyzed by them like I had been. The noise in my head has gotten much quieter and I have hope and joy back in my life. Very thankful for this drug.

Comment from: Vickie 55-64 Transgender 1 to 6 months Caregiver Published: January 21

Does your appetite ever come back? Went on parnate for 4 weeks with NO appetite. I am a small person that does not need to lose weight. Will my appetite ever come back on this drug.

Comment from: Jac888 55-64 Transgender 10 years or more Caregiver Published: September 09

This is the only drug that has worked for me. Went many years in a low mood. On this for 15 years now. I have very few food sensitivities. For some reason cinnamin causes it not to work. For me it took 3 days to work. My mood does come down sometimes, but that is life situations only. The young doctors will not prescribe it becasue of liability, the AMA, and drug companies don't make money on this old drug. I take 50mg every morning. The worse side effect is sexual. I (male) can not have sex for about 10 hours after taking it, but I can skip a day if need be.If you don't have insurance, you can buy from a Canadian distributor at about 1/3rd the price.

Comment from: Chris 55-64 Transgender less than 1 month Caregiver Published: June 12

I have more questions then a rating. I've been on Parnate about a month. Started slow at 10 mg now up to 20mg after about 3 1/2 weeks. It has helped my depression but the side effects are absolutely crazy. Dizziness, short of breath, anxiety and muscle pain plus neck pain. Has anyone have this happen to them?? If anyone has even some of these side effects can you please respond??? Ty

Comment from: Lani 65-74 Transgender 5 to less than 10 years Caregiver Published: December 06

I use to take Parvati when in living in California years ago. Miss the stability so much. Upon moving to east coast I was not able to get through local pharmacy and switched to Nardil (Not as effective)which then became hard to acquire. Through many different providers I never found any who were well versed on MAO use and alot of them refused to prescribe due to potential hypertensive crisis. I w as pretty much left with the ssri and snri which have been ho-hum. Effexors been the closest to Parvati but it still was the best for me.

Comment from: Oldie 55-64 Transgender 2 to less than 5 years Caregiver Published: November 06

Parnate has been a wonder drug for me. After eighteen admissions to a psychiatric hospital over seventeen years, I had tried many drugs in combinations without ongoing success until I tried Parnate. Currently 160 mg/day as it appears I'm a fast metaboliser of the drugs. Food restrictions are a minor issue.

Comment from: Old & Decrepit 55-64 Transgender 2 to less than 5 years Caregiver Published: November 03

Have been taking Parnate for over four years and it has been a great drug for controlling my severe depression and anxiety. And I have tried over twenty different drug and drug combinations. I find the food restrictions in practice to be a tiny problem. Highly, highly recommended drug.

Comment from: Walter 25-34 Male 5 to less than 10 years Patient Published: January 07

You are "treatment resistant" as long as you haven't tried a classical MAOI for depression. This drug has a very powerful antidepressant, anxiolytic and also anti-OCD effect. Much more effective than everything else what is legally available as "antidepressants". Side effects (especially insomnia and afternoon fatigue) can be very annoying but are overall not worse than what you get from SSRIs and all the other crap. The recommendations regarding diet restrictions are outdated (!!!)

Comment from: WAS 65-74 Female 5 to less than 10 years Patient Published: April 28

As with so many other reviewers, I tried multiple meds of multiple types, singly and in combination, to treat 50 years of depression. Some were effective for awhile and then lost their effectiveness. Some were ineffective from the beginning. I also had two ECT series (12 treatments in each series) with Ketamine as the anesthetic. Almost seven years ago my psychiatrist suggested Parnate. At that point I would have agreed to rat poison if she told me it might work. We did a standard slow increase in dosage. The primary side effects were insomnia and a sudden complete loss of energy in the late afternoon. I began to feel positive effect at 50 mg. 60 mg was better, but with only partial recovery. After searching the Internet I came up with a few old articles about mega-dosing Parnate. My psychiatrist agreed to increase the dose if I would take my blood pressure two hours after every dose. I'm now on 120 mg. Most of the time I feel quite good. I no longer have the "freight train smacked me" feeling in the afternoon. I continue to have insomnia and have learned to live with it. I'm very careful about the food I eat, especially when we eat out, and about over the counter meds. I've have never had a food reaction. Parnate helped me get back to a life worth living.

Comment from: Rejuvinated1155 35-44 Female 1 to 6 months Patient Published: July 02

Parnate has worked 10x better than any other anti-depressant I've ever taken (and I've tried loads of them). Diet is easy if you have the latest guidelines. I see a couple reviewers here have had the 1-2 hour high BP episodes, but these are pretty easy to avoid. If you get one, a benzodiazepine med will reverse it. Like I said though, just a couple dietary things to look out for - I have never had any problems, just overall blood pressure decrease (my BP was high anyway) and almost complete disappearance of my horrible depression and anxiety. I have my life back now.

Comment from: ssrissuck 35-44 Male 1 to less than 2 years Patient Published: June 12

I've dealt with major depressive disorder for 22 years and have always had to be on several anti-depressants at one time. They only lessened my symptoms in the best of cases, but did nothing most of the time. I've been on every antidepressant in addition to things like risperdal as an adjunct. I was on 450mg welbutrin, 60mg remeron and 120mg cymbalta concurrently with no effect when I decided to take the maoi plunge. That was 18 months ago. It's truly amazing to feel normal. I'd forgotten what that felt like. I have my life back. I do have to say the first couple of months were the most brutal med adjustment I've ever been through. I think most people would have given in and quit. I couldn't sleep, couldn't eat and generally felt like I was going out of my mind. Glad I stuck it out. After the first few months I've had no side effects besides a little afternoon fatigue. I've had no trouble with diet and slowly tested items to see what I could get away with. Now I eat pretty much what I want with the exception of "real" cheese (no problem with bland supermarket colbys, mild cheddars, jack etc.) I've never had a hypertensive reaction.

Comment from: kevin M 45-54 Female 10 years or more Patient Published: December 13

I have taken parnate for 25 years. It saved my life and is the only medication (I tried many) that has worked for me. I have had insomnia since I started with it in 1990. This has been ameliorated, but not resolved, by addition of ambien, neurontin and trazedone. I take a very high dose of parnate (170 mg/day-110 mg in the morning, 60 mg seven hours later). In 2001, I went off parnate to try to find a safer medication and became very ill. Although going back on parnate did not work at first, the addition of zyprexa to the parnate miraculously brought me immediately out of profound depression. I have had two hypertensive crises. I am very careful about diet and rarely eat out. I am not clear what caused my crises, but both occurred after eating at restaurants. I have to be careful about stress, exposure to too much sun or to high heat (e.g., saunas) and physical exertion, as these can cause dangerous side effects. With it all, I can be nothing but thankful for this life-saving drug.

Comment from: Schuylerdare 45-54 Female 6 months to less than 1 year Patient Published: December 12

I had tried a lot of different medications that did not work and was doing ECT treatments when my doctor suggested Parnate. Within a week it was like someone had flipped a switch and I could actually smile and mean it. I had four suicide attempts and was continually cutting. I have not had that feeling since going on the Parnate and am extremely happy. I will say the diet restrictions are a challenge until you get used to them but definitely worth it.

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow
Comment from: 25-34 Female 1 to less than 2 years Patient Published: October 06

After I have tried many other antidepressants that did not help, my doc gave me this. First my condition got better and I thought "Yeah, finally I found something that helps me", but after a few months my mood began to drop again. I still felt better than before, but far away from good. So I took a higher dose and I felt better again, but with the side effect that my blood pressure was too low. So I changed back to the lower dose. I don't get a high blood pressure when eating high thyramine food, so I eat what I want.