Triamterene-Hydrochlorothiazide

Triamterene-Hydrochlorothiazide is a combination medication used for the treatment of high blood pressure and fluid retention (edema). 

• Triamterene-Hydrochlorothiazide is available under the following different brand names: Dyazide, Maxzide 

Common side effects of Triamterene-Hydrochlorothiazide include:

• Stomach pain,
• Nausea,
• Diarrhea,
• Constipation,
• Dizziness,
• Headache,
• Blurred vision, and
• Dry mouth

Serious side effects of Triamterene-Hydrochlorothiazide include:

• Blurred vision,
• Tunnel vision,
• Eye pain,
• Seeing halos around lights,
• Lightheadedness,
• Fast, slow, or uneven heart rate,
• Dark urine,
• Clay-colored stool,
• Yellowing of eyes or skin (jaundice),
• Severe pain in the upper stomach or back,
• Nausea,
• Vomiting,
• Fever,
• Sore throat,
• Headache,
• Skin rash that may blister and peel,
• Numbness or tingling,
• Muscle weakness,
• Loss of movement in any body part,
• Leg cramps,
• Fluttering in the chest,
• Increased thirst and urination,
• Feeling restless,
• Little or no urination,
• Painful or difficult urination,
• Swelling in the feet or ankles,
• Tiredness,
• Short of breath,
• Joint pain or swelling,
• Swollen glands,
• Muscle aches,
• Chest pain,
• Unusual thoughts or behavior, and
• Patchy skin color

Rare side effects of Triamterene-Hydrochlorothiazide include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Capsule

• 37.5 mg/25 mg
• 50 mg/25 mg 

Tablet

• 37.5 mg/25 mg
• 75 mg/50 mg

Hypertension

Adult dosage

• 1-2 tablets/capsules (37.5-50 mg triamterene and 25 mg HCTZ) orally once a day
• 1 tablet (75 mg triamterene and 50 mg HCTZ) orally once a day

Edema

Adult dosage

• 1-2 tablets/capsules (37.5-50 mg triamterene and 25 mg HCTZ) orally once a day
• 1 tablet (75 mg triamterene and 50 mg HCTZ) orally once a day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Triamterene-Hydrochlorothiazide has severe interactions with no other drugs.
• Triamterene-Hydrochlorothiazide has serious interactions with the following drugs
  • amiloride
  • aminolevulinic acid oral
  • aminolevulinic acid topical
  • carbamazepine
  • cyclophosphamide
  • cyclosporine
  • dofetilide
  • drospirenone
  • eplerenone
  • isocarboxazid
  • lofexidine
  • methyl aminolevulinate
  • potassium acid phosphate
  • potassium chloride
  • potassium citrate
  • potassium phosphates, IV
  • spironolactone
  • squill
• Triamterene-Hydrochlorothiazide has moderate interactions with at least 204 other drugs.
• Triamterene-Hydrochlorothiazide has minor interactions with at least 175 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to triamterene, hydrochlorothiazide, or sulfonamides (hydrochlorothiazide is a sulfonamide)
• Concomitant administration with potassium-rich diets, or any other form of potassium supplementation
• Chronic or significant renal insufficiency or significant renal impairment
• Anuria
• Hyperkalemia above 5.5 mEq/L

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Triamterene-Hydrochlorothiazide?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Triamterene-Hydrochlorothiazide?”

Cautions

• Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with a history of sulfonamide or penicillin allergy
• Hydrochlorothiazide can cause electrolyte disturbances including hypokalemia, hypochloremic alkalosis, and hyponatremia
• Photosensitization may occur; instruct patients to protect their skin from the sun and undergo regular skin cancer screening
• Use with caution in diabetes mellitus, hepatic impairment, gout, hypercalcemia, hypercholesterolemia, kidney stones, parathyroid disease, systemic lupus erythematosus, and renal impairment
• Risk of cross-reaction in patients with allergy to sulfonylurea, sulfonamides, thiazides, loop diuretics, or carbonic anhydrase may occur

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy.
• Lactation
  • Not recommended; discontinue the drug or do not nurse