Trospium Chloride

Trospium Chloride is a prescription medication used for the treatment of overactive bladder. 

• Trospium Chloride is available under the following different brand names: Sanctura, Sanctura XR

Adult dosage

Tablet

• 20 mg

Capsule, extended-release

• 60 mg

Overactive Bladder

Adult and geriatric dosage

• Immediate release: 20 mg orally twice daily
• Extended-Release: 60 mg orally every day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”.

Common side effects of Trospium Chloride include:

• dry mouth or throat,
• headache,
• mild constipation,
• upset stomach,
• gas,
• dizziness,
• drowsiness, and
• dry eyes.

Serious side effects of Trospium Chloride include:

• hives,
• difficulty breathing,
• swelling of the face, lips, tongue, or throat,
• severe stomach pain or bloating,
• severe constipation,
• urinating less than usual or not at all,
• confusion, and
• hallucinations

Rare side effects of Trospium Chloride include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Trospium Chloride has severe interactions with no other drugs.
• Trospium Chloride has serious interactions with the following drugs:
  • glycopyrronium tosylate topical
  • pramlintide
  • revefenacin
  • secretin
• Trospium Chloride has moderate interactions with at least 101 other drugs.
• Trospium Chloride has minor interactions with the following drugs:
  • dimenhydrinate
  • donepezil
  • galantamine
  • levodopa

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Urinary/gastric retention
• Uncontrolled narrow-angle glaucoma
• Hypersensitivity

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Trospium Chloride?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Trospium Chloride?”

Cautions

• Use caution in renal impairment, geriatric patients, moderate or severe hepatic dysfunction
• Angioedema of the face, lips, tongue, and/or larynx reported (including with 1st dose); if the involvement of the tongue, hypopharynx, or larynx occurs promptly discontinue; promptly provide appropriate therapy and/or measures necessary to ensure a patent airway function
• Administer with caution to patients with clinically significant bladder outflow obstruction or gastrointestinal obstructive disorders due to risk of urinary or gastric retention; use with caution in patients with conditions such as ulcerative colitis, intestinal atony, and myasthenia gravis
• To administer, must carefully monitor patients with controlled narrow-angle glaucoma; benefits should outweigh risks
• Somnolence reported; advise patients not to drive or operate heavy machinery until they know how therapy affects them
• Drug substantially excreted by the kidney; effects of moderate renal impairment on systemic exposure are not known but systemic exposure is likely increased; risk of anticholinergic adverse reactions (including dry mouth, constipation, dyspepsia, urinary tract infection, and urinary retention) is expected to be greater in patients with moderate renal impairment

Pregnancy and Lactation

• Use with caution if benefits outweigh risks during pregnancy
• Lactation
  • Excretion in milk unknown; use with caution