Typhoid polysaccharide vaccine

The typhoid polysaccharide vaccine is a typhoid vaccine used for the prevention of typhoid fever in adults and children who are at least 2 years old. 

• Typhoid polysaccharide vaccine is available under the following different brand names: Typhim Vi

Common side effects of the Typhoid polysaccharide vaccine include:

• Injection site reactions (pain, tenderness, redness, swelling, or a hard lump),
• Low fever,
• Nausea,
• Diarrhea,
• Stomach pain, or
• Headache.

Serious side effects of the Typhoid polysaccharide vaccine include:

• Fever,
• Swollen glands,
• Rash or itching,
• Body aches,
• Tremors,
• General ill feelings, or
• Feeling like you might pass out.

Rare side effects of the Typhoid polysaccharide vaccine include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Injection solution

• 25 mcg derived from S. Typhi Ty2 strain/0.5 mL
• Typhoid Fever Prophylaxis
• Adult dosage
• 0.5 mL Intramuscular once 2 weeks before expected exposure
• Booster: 0.5 mL Intramuscular every 2 years, under conditions of repeated or continued exposure to the S Typhi organism recommended
• Pediatric dosage
• Children below 2 years: Safety and efficacy not established
• Children above 2 years: 
  • 0.5 mL Intramuscular once 2 weeks before expected exposure
  • Booster: 0.5 mL Intramuscular every 2 years, under conditions of repeated or continued exposure to the S Typhi organism recommended

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Typhoid polysaccharide vaccine has severe interactions with the following drugs
  • belimumab
  • ibrutinib
  • ixekizumab
  • lomustine
  • mechlorethamine
  • melphalan
  • onasemnogene abeparvovec
  • oxaliplatin
  • procarbazine
  • secukinumab
• Typhoid polysaccharide vaccine has serious interactions with at least 49 other drugs.
• Typhoid polysaccharide vaccine has moderate interactions with the following drugs:
  • betibeglogene autotemcel
  • certolizumab pegol
  • mercaptopurine
  • methotrexate
  • obinutuzumab
  • ponesimod
  • traveler’s diarrhea and cholera vaccines inactivated
• Typhoid polysaccharide vaccine has minor interactions with the following drugs:
  • chloroquine
  • ethotoin
  • fosphenytoin
  • phenytoin

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity 

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Typhoid polysaccharide vaccine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Typhoid polysaccharide vaccine?”

Cautions

• Complete vaccination 1 week before exposure (endemic areas = Africa, Asia, Central, and S. America)
• Efficacy is 70-96% for parenteral administration
• May administer Hib, DTP, OPV, IPV, MMR, influenza, and hepatitis B vaccines at the same time
• Syncope accompanied by transient visual disturbances reported with injectable vaccines; procedures should be in place to prevent falling injury and manage syncopal reactions
• Not for the treatment of typhoid fever
• Not all vaccine recipients become protected against typhoid fever; take the necessary precautions to avoid ingesting food or water that may be contaminated
• Administer at least 2 weeks before expected exposure
• Avoid administration in patients with moderate or severe acute illness
• Provides protection against the risk of infection related to Salmonella typhi, but gives no protection against Salmonella paratyphi A or B, non-S typhi species of Salmonella enterica serovar Typhi, or other bacteria that cause enteric disease
• If administered to persons deficient in producing antibodies, whether due to genetic defect, immunodeficiency disease, or immunosuppressive therapy, expected immune response may not be obtained; this includes patients with asymptomatic or symptomatic HIV-infection, severe combined immunodeficiency, hypogammaglobulinemia, or agammaglobulinemia; altered immune states due to diseases such as leukemia, lymphoma, or generalized malignancy; or immune system compromised by treatment with corticosteroids, alkylating drugs, antimetabolites or radiation
• Epinephrine injection (1:1000) must be immediately available following immunization should an anaphylactic or other allergic reaction occur due to any component of the vaccine
• Before an injection of any vaccine, all known precautions should be taken to prevent adverse reactions; this includes a review of the patient's history concerning possible hypersensitivity to the vaccine or similar vaccines
• Acute infection or febrile illness may be the reason for delaying the use of the Typhim Vi vaccine except when, in the opinion of the physician, withholding the vaccine entails a greater risk

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy.

Lactation

• Not known if excreted in the breast; use caution