Unoprostone Ophthalmic

Unoprostone ophthalmic is used to lower intraocular pressure (IOP) with open-angle glaucoma and to lower IOP with ocular hypertension.

Unoprostone ophthalmic is available under the following different brand names: Rescula.

Dosage Forms and Strengths

Ophthalmic Solution

• 15%

Dosage Considerations – Should be Given as Follows:

Open-Angle Glaucoma

• Indicated to lower intraocular pressure (IOP) with open-angle glaucoma
• 1 drop in affected eye(s) twice daily
• Ocular Hypertension
• Indicated to lower IOP with ocular hypertension
• 1 drop in affected eye(s) B twice daily
• Children under 18 years: Safety and efficacy not established

Common side effects of unoprostone ophthalmic include:

• Burning/stinging
• Dry eyes
• Itching
• Increased length of eyelashes
• Conjunctival injection
• Abnormal vision
• Eyelid disorder
• Foreign body sensation
• Tearing disorder
• Decreased length of eyelashes
• Inflammation/infection of eyelids
• Cataracts
• Conjunctivitis
• Corneal lesion/erosion
• Eye discharge/hemorrhage/pain
• Keratitis
• Irritation
• Sensitivity to light (photophobia)
• Vitreous disorder
• Blurred vision
• Conjunctival redness

Less common side effects of unoprostone ophthalmic include:

• Hyperpigmentation of the eyelid or iris and increased number of eyelashes
• Acute elevated IOP
• Color blindness
• Corneal deposits
• Corneal edema
• Corneal opacity
• Double vision
• Optic atrophy
• Drooping eyelids
• Retinal hemorrhage
• Visual field defect

Postmarketing side effects of unoprostone ophthalmic reported include:

• Eye inflammation
• Dry mouth
• Nausea
• Vomiting
• Palpitations

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Unoprostone ophthalmic has no listed severe interactions with other drugs.
 

Serious interactions of unoprostone ophthalmic include:

• bimatoprost
• latanoprost
• latanoprostene bunod ophthalmic
• tafluprost
• travoprost ophthalmic
• Unoprostone ophthalmic has moderate interactions with at least 32 different drugs.

Unoprostone ophthalmic has no listed mild interactions with other drugs.
 

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings
 

This medication contains unoprostone ophthalmic. Do not take Rescula if you are allergic to unoprostone ophthalmic or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Hypersensitivity

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Unoprostone Ophthalmic?”

Long-Term Effects

• See "What Are Side Effects Associated with Using Unoprostone Ophthalmic?”

Cautions

• Increased pigmentation may occur due to increased melanin content in the iris, eyelid periorbital tissues, and eyelashes
• May exacerbated active intraocular inflammation (e.g., uveitis)
• Macular edema, including cystoid macular edema, reported; caution in aphakic patients or pseudophakic patients with the torn posterior lens capsule

Pregnancy and Lactation

Use unoprostone ophthalmic with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

It is unknown if unoprostone ophthalmic is distributed into human milk. Use caution while breastfeeding.