Urea/Hydrocortisone Topical

Urea/hydrocortisone topical is used for relief of inflammation and itching associated with corticosteroid-responsive dermatoses (skin problems).

Urea/hydrocortisone topical is available under the following different brand names: Carmol HC and U-Cort.

Dosages of Urea/Hydrocortisone Topical:

Dosage Forms and Strengths

Topical Cream

• 10%/1%

Dosage Considerations – Should be Given as Follows:

Dermatoses

• Relief of inflammation and itching associated with corticosteroid-responsive dermatoses
• Apply to the affected area every 6-12 hours; discontinue therapy when control achieved
• If no improvement within 2 weeks, reassess the diagnosis

Side effects of urea/hydrocortisone topical include:

• Burning
• Itching
• Irritation
• Dryness
• Folliculitis
• Abnormal hair growth on the body
• Acne
• Skin lightening
• Perioral dermatitis
• Allergic contact dermatitis
• Skin softening and breakdown
• Secondary infection
• Skin atrophy
• Stretch marks
• Sweat rash

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Urea/hydrocortisone topical has no listed severe interactions with other drugs.
Urea/hydrocortisone topical has no listed serious interactions with other drugs.
 

Moderate interactions of urea/hydrocortisone topical include:

• collagenase

Mild interactions of urea/hydrocortisone topical include:

• vasopressin

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings
 

This medication contains urea/hydrocortisone topical. Do not take Carmol HC or U-Cort if you are allergic to urea/hydrocortisone topical or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Hypersensitivity to any components of the preparation
• Hepatic insufficiency

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Urea/Hydrocortisone Topical?”

Long-Term Effects

• See "What Are Side Effects Associated with Using Urea/Hydrocortisone Topical?”

Cautions

• Prolonged use may result in fungal or bacterial infection
• Contains sodium metabisulfite, which may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people
• Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria
• Conditions that augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use and the addition of occlusive dressings
• Evaluate susceptible patients periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests; If HPA axis suppression is noted, withdraw the drug, reduce the frequency of application, or substitute less potent steroid

Pregnancy and Lactation

Use urea/hydrocortisone topical with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.