What Is Voreloxin Used For and How Does it Work?
Voreloxin has an investigational/orphan status to treat acute myelogenous leukemia (AML) and investigational status to treat ovarian cancer, platinum-resistant.
Voreloxin is available under the following different brand names: N/A.
What Are the Dosages of Voreloxin?
Dosages of Voreloxin:
- Consult your doctor
Dosage Considerations – Should be Given as Follows:
Acute Myelogenous Leukemia (Investigational/Orphan Status)
- Refractory/relapsed AML: 80-90 mg/m2 intravenously (IV) on days 1 and 4 (with cytarabine)
- Elderly patients with newly diagnosed AML: 72 mg/m2 IV for 2 doses on days 1 and 8
Ovarian Cancer, Platinum-Resistant (Investigational)
- 60-75 mg/m2 IV every 4 weeks; infuse IV over 5-10 min
Not applicable in pediatric patients.
What Are Side Effects Associated with Using Voreloxin?
Side Effects of Voreloxin include:
- Mucositis (dose-limiting)
- Low white blood cell count (neutropenia)
- Fatigue
- Anemia
- Nausea
- Vomiting
- Low blood potassium (hypokalemia)
- Loss of appetite
- Upper gastrointestinal mucosal inflammation
- Diarrhea/colitis
- Low blood phosphates (hypophosphatemia)
- Low blood calcium (hypocalcemia)
- Dehydration
- Confusion
- Shortness of breath
- Infections (bacterial pneumonia, sepsis, bacteremia, other)
- Low blood pressure (hypotension)
What Other Drugs Interact with Voreloxin?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Voreloxin has no listed severe interactions with other drugs.
Voreloxin has no listed serious interactions with other drugs.
Voreloxin has no listed moderate interactions with other drugs.
Voreloxin has no listed mild interactions with other drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
What Are Warnings and Precautions for Voreloxin?
Warnings
This medication contains voreloxin. Do not take N/A if you are allergic to voreloxin or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
Contraindications
- Data limited, unknown
Effects of Drug Abuse
- No information available
Short-Term Effects
- See "What Are Side Effects Associated with Using Voreloxin?"
Long-Term Effects
- See "What Are Side Effects Associated with Using Voreloxin?"
Cautions
- Data limited, unknown
Pregnancy and Lactation
Use voreloxin during pregnancy in LIFE-THREATENING emergencies when no safer drug is available. There is positive evidence of human fetal risk.
It is not known whether voreloxin is distributed in breast milk. Do not breastfeed while using voreloxin.
