Xenon Xe 129 Hyperpolarized

Xenon Xe 129 Hyperpolarized is a diagnostic imaging agent used with MRI for the evaluation of lung ventilation. 

• Xenon Xe 129 Hyperpolarized is available under the following different brand names: Xenoview

Common side effects of Xenon Xe 129 Hyperpolarized include:

• headache,
• dizziness, and
• sore throat

Serious side effects of Xenon Xe 129 Hyperpolarized include:

• hives,
• difficulty breathing,
• swelling of the face, lips, tongue, or throat,
• decreased oxygen saturation in the blood,
• anxiety,
• fatigue,
• intrusive thoughts,  
• numbness,
• tingling,
• a feeling of intense excitement or happiness, and
• dizziness

Rare side effects of Xenon Xe 129 Hyperpolarized include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out. 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Gas, oral inhalation

• Each 1,000-mL dose delivery bag contains at least 75 mL dose equivalent (DE) of hyperpolarized xenon Xe 129 in a volume of 250-750 mL total xenon

Lung Ventilation Evaluation

Adult dosage

• Recommended target dose: 75-100 mL DE of hyperpolarized xenon Xe 129 by oral inhalation
• DE defined by the following formula
  • DE = (total volume xenon gas) × (fraction of xenon Xe 129 isotopic enrichment in the xenon gas) × (fraction of hyperpolarization)
  • Total volume of xenon gas is 250-750 mL
  • Fraction of xenon Xe 129 isotopic enrichment is above 80% and the mean fraction of hyperpolarization is at least 38-54% after polarization of 250 mL of xenon gas
• Example
  • If 300 mL of total xenon gas with 83% enrichment of xenon Xe 129 is dispensed from HPX Hyperpolarizer at 40% hyperpolarization
  • DE = 300 mL × 0.83 × 0.40 = 99.6 mL

Pediatric dosage

• Aged below 12 years: Safety and efficacy not established
• Aged above 5 years
  • Recommended target dose: 75-100 mL DE of hyperpolarized xenon Xe 129 by oral inhalation
  • DE defined by the following formula
    • DE = (total volume xenon gas) × (fraction of xenon Xe 129 isotopic enrichment in the xenon gas) × (fraction of hyperpolarization)
    • Total volume of xenon gas is 250-750 mL
    • Fraction of xenon Xe 129 isotopic enrichment is above 80% and the mean fraction of hyperpolarization is at least 38-54% after polarization of 250 mL of xenon gas
• Example
  • If 300 mL of total xenon gas with 83% enrichment of xenon Xe 129 is dispensed from HPX Hyperpolarizer at 40% hyperpolarization
  • DE = 300 mL × 0.83 × 0.40 = 99.6 mL

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Xenon Xe 129 Hyperpolarized has no noted severe interactions with any other drugs.
• Xenon Xe 129 Hyperpolarized has no noted serious interactions with any other drugs.
• Xenon Xe 129 Hyperpolarized has no noted moderate interactions with any other drugs.
• Xenon Xe 129 Hyperpolarized has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• None

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Xenon Xe 129 Hyperpolarized?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Xenon Xe 129 Hyperpolarized?”

Cautions

• Risk of decreased image quality from supplemental oxygen
• Supplemental oxygen administered simultaneously with xenon Xe hyperpolarized inhalation can cause degradation of image quality due to depolarization
• For patients on supplemental oxygen, withhold oxygen inhalation for 2 breaths before o xenon Xe hyperpolarized inhalation, and resume oxygen inhalation immediately following the imaging breath hold
• Risk of transient hypoxia
  • Inhalation of an anoxic gas may cause transient hypoxemia in susceptible
  • Monitor all patients for oxygen desaturation and symptoms of hypoxemia, and treat as clinically indicated

Pregnancy and Lactation

• Minimally absorbed systemically following inhalation; maternal use not expected to result in fetal drug exposure
• Lactation
  • Minimally absorbed systemically following inhalation; breastfeeding is not expected to result in drug exposure to the infant
  • There is no information on the presence of hyperpolarized xenon Xe 129 in human milk, its effect on breastfed infants, or its effect on milk production