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Ephedrine (Ephedrine): Side Effects, Uses, Dosage, Interactions, Warnings

Ephedrine

Last updated on RxList: 8/10/2020

Drug Summary

What Is Ephedrine?

Ephedrine is a central nervous system stimulant used to treat breathing problems (as a bronchodilator), nasal congestion (as a decongestant), low blood pressure problems (orthostatic hypotension), or myasthenia gravis. Ephedrine is also used to treat narcolepsy, menstrual problems (dysmenorrhea), or urine-control problems. Ephedrine is available in generic form.

What Are Side Effects of Ephedrine?

Common side effects of Ephedrine usually occur with larger doses and include:

  • nervousness,
  • anxiety,
  • dizziness,
  • spinning sensation (vertigo),
  • headache,
  • nausea,
  • loss of appetite,
  • trouble sleeping (insomnia),
  • fast heart rate,
  • palpitations,
  • sweating,
  • vomiting,
  • weight loss, and
  • difficult or painful urination.

Dosage for Ephedrine

The dosage of Ephedrine is based on the patient's medical condition and response to therapy. For prescription Ephedrine, do not exceed 150 mg per day in adults or 75 mg per day in children.

What Drugs, Substances, or Supplements Interact with Ephedrine?

Ephedrine may interact with other adrenalin-like drugs, MAO inhibitors, beta-blockers, blood pressure medicine, tricyclic antidepressants, diuretics (water pills), digoxin, atropine, theophylline, oxytocin, or St John's wort. Tell your doctor all medications you are taking.

Ephedrine During Pregnancy and Breastfeeding

Ephedrine should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk. Due to the potential risk to the infant, breastfeeding while using this drug is not recommended.

Additional Information

Our Ephedrine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

For IM, IV or SC Use 50 mg/mL pH 4.5 - 7.0

Description for Ephedrine

Ephedrine Sulfate Injection, USP is a sterile solution of 50 mg ephedrine sulfate in water for injection.

Ephedrine occurs as fine, white, odorless crystals or powder and darkens on exposure to light. It is freely soluble in water and sparingly soluble in alcohol.

The chemical name for ephedrine sulfate is (C10H15NO)2•H2SO4 benzenemethanol α - [1 - (methylamino) ethyl] - sulfate (2:1) (salt). Its molecular weight is 428.54.

The structural formula is:

EPHEDRINE SULFATE Structural Formula Illustration

Uses for Ephedrine

Ephedrine Sulfate Injection, USP is indicated in the treatment of allergic disorders, such as bronchial asthma. The drug has long been used as a pressor agent, particularly during spinal anesthesia when hypotension frequently occurs. In Stokes-Adams syndrome with complete heart block, ephedrine has a value similar to that of epinephrine. It is indicated as a central nervous system stimulant in narcolepsy and depressive states. It is also used in myasthenia gravis.

Dosage for Ephedrine

Adults

The usual parenteral dose is 25 to 50 mg given subcutaneously or intramuscularly. Intravenously, 5 to 25 mg may be administered slowly, repeated in 5 to 10 minutes, if necessary.

Children

The usual subcutaneous or intramuscular dose is 0.5 mg/kg of body weight or 16.7 mg/square meter of body surface every 4 to 6 hours.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

HOW SUPPLIED

Ephedrine Sulfate Injection, USP, 50 mg/mL, 1 mL per vial, NDC 55390-875-01

Packed 25 vials per carton. Protect from light.

Manufactured for: Bedford Laboratories™ Bedford, OH 44146. Manufactured by: Ben Venue Laboratories Inc. Bedford, OH 44146. Revised 10/01.

Side Effects for Ephedrine

With large doses of ephedrine sulfate most patients will experience nervousness, insomnia, vertigo, headache, tachycardia, palpitation and sweating. Some patients have nausea, vomiting and anorexia. Vesical sphincter spasm may occur and result in difficult and painful urination. Urinary retention may develop in males with prostatism.

Precordial pain and cardiac arrhythmias may occur following administration of Ephedrine Sulfate Injection, USP.

Drug Abuse And Dependence

Prolonged abuse of Ephedrine Sulfate Injection, USP can lead to symptoms of paranoid schizophrenia. When this occurs, patients exhibit such physical signs as tachycardia, poor nutrition and hygiene, fever, cold sweat and dilated pupils.

Some measure of tolerance may develop with prolonged or excessive use but addiction does not occur. Temporary cessation of medication and subsequent readministration restores its effectiveness.

Drug Interactions for Ephedrine

Concurrent use of ephedrine sulfate with general anesthetics, especially cyclopropane or halogenated hydrocarbons or digitalis glycosides may cause cardiac arrhythmias, since these medications may sensitize the myocardium to the effects of ephedrine sulfate.

Therapeutic doses of ephedrine sulfate can inhibit the hypotensive effect of guanethidine, bethanidine, and debrisoquin by displacing the adrenergic blockers from their site of action in the sympathetic neurons. The effect in man is seen as a relative or a complete blockade of the antihypertensive drug by a sudden rise in blood pressure. Concomitant use of Ephedrine Sulfate Injection, USP and oxytocics may cause severe hypotension.

Monoamine oxidase inhibitors may potentiate the pressor effect of ephedrine sulfate, possibly resulting in a hypertensive crisis. Ephedrine Sulfate Injection, USP should not be administered during or within 14 days following the administration of MAO inhibitors.

Warnings for Ephedrine

No information provided.

Precautions for Ephedrine

General

Special care should be used when administering Ephedrine Sulfate Injection, USP to patients with heart disease, angina pectoris, diabetes, hyperthyroidism, prostatic hypertrophy or hypertension and to patients receiving digitalis. Prolonged use may produce a syndrome resembling an anxiety state. Tolerance to ephedrine sulfate may develop, but temporary discontinuance to the drug restores its original effectiveness.

Pregnancy Category C

Animal reproduction studies have not been conducted with Ephedrine Sulfate Injection, USP. Also, it is not known whether the drug can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Ephedrine Sulfate Injection, USP should be given to a pregnant woman only if clearly indicated.

It is not known what effect Ephedrine Sulfate Injection, USP may have on the newborn or on the child's later growth and development when the drug is administered to the mother just before or during labor.

Nursing Mothers

Ephedrine sulfate is excreted in breast milk. Use by nursing mothers is not recommended because of the higher than usual risk for infants.

Overdose Information for Ephedrine

Symptoms

The principal manifestation of ephedrine sulfate poisoning is convulsions. In acute poisoning the following signs and symptoms may occur: nausea, vomiting, chills, cyanosis, irritability, nervousness, fever, suicidal behavior, tachycardia, dilated pupils, blurred vision, opisthotonos, spasms, convulsions, pulmonary edema, gasping respirations, coma and respiratory failure. Initially, the patient may have hypertension, followed later by hypotension accompanied by anuria.

Treatment

If respirations are shallow or cyanosis is present, artificial respiration should be administered. Vasopressors are contraindicated. In cardiovascular collapse blood pressure should be maintained.

Antidote

For hypertension, 5 mg phentolamine mesylate diluted in saline may be administered slowly intravenously, or 100 mg may be given orally. Convulsions may be controlled by diazepam or paraldehyde. Cool applications and dexamethasone 1 mg/kg, administered slowly intravenously, may control pyrexia.

Contraindications for Ephedrine

Allergic reactions to ephedrine sulfate are rare. The hypersensitivity, if known, is a specific contraindication. Patients hypersensitive to other sympathomimetics may also be hypersensitive to ephedrine sulfate.

Clinical Pharmacology for Ephedrine

Ephedrine sulfate is a potent sympathomimetic that stimulates both α and β receptors and has clinical uses related to both actions. Its peripheral actions, which it owes in part to the release of norepinephrine, simulate responses that are obtained when adrenergic nerves are stimulated. These include an increase in blood pressure, stimulation of heart muscle, constriction of arterioles, relaxation of the smooth muscle of the bronchi and gastrointestinal tract, and dilation of the pupils. In the bladder, relaxation of the detrusor muscle is not prominent, but the tone of the trigone and vesicle sphincter is increased.

Ephedrine sulfate also has a potent effect on the CNS. It stimulates the cerebral cortex and subcortical centers, which accounts for its use in narcolepsy.

The cardiovascular responses reported in man include moderate tachycardia, unchanged or augmented stroke volume, enhanced cardiac output, variable alterations in peripheral resistance and usually a rise in blood pressure. The action of ephedrine is more prominent on the heart than on the blood vessels. Ephedrine sulfate increases the flow of coronary, cerebral and muscle blood.

In patients with myasthenia gravis, administration of Ephedrine Sulfate Injection, USP produces a real but modest increase in motor power. The exact mechanism by which ephedrine sulfate affects skeletal muscle contractions is unknown.

Patient Information for Ephedrine

No information provided. Please refer to the PRECAUTIONS section.

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