uses
What is Kineret used for?Kineret (anakinra) is commonly used to treat the following conditions.Rheumatoid arthritis (RA). RA is an autoimmune condition that causes your immune system to attack the lining of your joints.Neonatal-onset multisystem inflammatory disease (NOMID). NOMID is a rare condition that causes inflammation and usually starts soon after birth. It is one of the cryopyrin-associated periodic syndromes (CAPS). CAPS are rare conditions that cause problems with the immune system.Deficiency of interleukin-1 receptor antagonist (DIRA). DIRA is a rare inherited condition in newborn babies where the body does not make a protein that helps control inflammation. This protein is called interleukin-1 receptor antagonist. Not having this protein can lead to severe inflammation.Kineret may also be used for other conditions as determined by your health care provider.How does Kineret work (mechanism of action)?Kineret works by blocking the effects of a substance called interleukin-1 (IL-1). This substance is normally made by the body and is part of your body’s response to inflammation. Blocking the effects of this substance can help treat the symptoms of certain inflammatory conditions.How is Kineret supplied (dosage forms)?Brands and other namesKineretDosage forms and strengths100 mg/0.67 mL single-dose prefilled syringesHow should I store Kineret?Kineret should be stored in the refrigerator, between 36 F and 46 F (2 C and 8 C). Do not freeze or shake it. Protect Kineret from light.
how to use
liquid that is injected under the skin
drug interactions
Does Kineret interact with foods or drinks?There are no known interactions between Kineret and foods or drinks.It is unknown if drinking alcohol will affect Kineret.Does Kineret interact with other medicines (drug interactions)?Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.In particular, make sure that you discuss if you are using any medicine called a tumor necrosis factor (TNF) blocker, such as adalimumab (Humira and others) or etanercept (Enbrel and others).This may not be a complete list of medicines that can interact with Kineret. Always check with your health care provider.
side effects
What are the most common side effects of Kineret?The most common side effects of Kineret are listed below. These side effects may vary depending on the condition that is being treated. Tell your health care provider if you have any of these side effects that bother you.Pain, itching, swelling, or redness near the injection siteInfection in the nose or throat, sore throat, or common cold symptomsHeadacheNausea or vomitingDiarrheaJoint painFever or flu-like symptomsStomach painSkin rashStomach fluThere may be other side effects of Kineret that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of Kineret?While less common, the most serious side effects of Kineret are described below, along with what to do if they happen.Severe Allergic Reactions. Kineret may cause allergic reactions, including a specific type of allergic reaction called DRESS. DRESS stands for drug reaction with eosinophilia and systemic symptoms. It is also sometimes called multiorgan hypersensitivity. This is a reaction that can affect multiple parts of the body, including your liver, kidneys, and heart. Stop using Kineret and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartItching, skin rash, or pale red bumps on the skin called hivesFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatShortness of breath, trouble swallowing, or throat tightnessSwelling in your feet, ankles, or legsNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painDark-colored peeYour skin or the whites of your eyes turning yellowish in color (also called jaundice)Infections. Kineret can increase your risk of infections, including serious infections. The risk is higher if you use certain other medicines. Call your health care provider right away if you have an infection or any of the following symptoms.Burning or stinging when you pee Cough or coughing up bloodFever, sweats, chills, or muscle achesShortness of breathDiarrhea or stomach painWeight lossSoresLow Neutrophil Levels (Neutropenia). Kineret may cause low levels of a type of white blood cell (called neutrophils), which is known as neutropenia. Neutrophils help prevent infection. Having a low level of neutrophils may increase your risk of infection. Tell your health care provider right away if you have any of the following symptoms of low neutrophil levels.Fever, chills, or sweatsTirednessSore throat, cough, or shortness of breathMouth or throat soresSwollen lymph nodes
overdose and misseddose
What should I do if I accidentally use too much Kineret?If you or someone else has used too much Kineret, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of Kineret?If you miss a dose, talk to your health care provider to find out when you should use your next dose.
warnings and Precautions
Who should not use Kineret?Allergies to Ingredients. People who are allergic to any of the following should not use Kineret.AnakinraKineretProteins made by bacteria called Escherichia coli (E. coli) Any of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in Kineret.What should I know about Kineret before using it?Do not use Kineret unless it has been prescribed to you by a health care provider. Use it as prescribed.Do not share Kineret with other people, even if they have the same condition as you. It may harm them.Keep Kineret out of the reach of children. Since this medicine should be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.This medicine is injected under the skin. Read and follow the instructions that come with the product. Make sure that you or a caregiver understands how to properly prepare and use the medicine. If you have any questions, talk to your health care provider.Kineret may commonly cause injection site reactions, such as redness, pain, itching, swelling, or bruising where it is injected. Most of these reactions are mild, happen early in treatment, and last about 14 to 28 days. Do not inject Kineret into skin that is already red or swollen. Take the medicine out of the refrigerator and leave it at room temperature for 30 minutes before injecting. Call your health care provider if you have symptoms that bother you or do not go away.Keep all appointments with your health care provider, including for blood work, before starting and while using Kineret.People who are 65 and older can be at greater risk for some side effects from Kineret. Talk to your health care provider about your risks if you are in this age group.What should I tell my health care provider before using Kineret?Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Kineret is right for you.In particular, make sure that you discuss any of the following.Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines right before or while using Kineret. Tell your health care provider about any vaccines you have recently received or have scheduled.Current and Past Health Conditions. Tell your health care provider if you have any of the following.Kidney problemsAn infection, especially one that keeps coming back or will not go awayTuberculosis (TB), or you have been in close contact with someone who has tuberculosisA weak immune systemOther Medicines and Supplements. Kineret may interact with other medicines and supplements. Before using Kineret, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.Pregnancy. It is not known if or how Kineret could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.Breastfeeding. It is not known if Kineret passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will advise you if you should use Kineret while breastfeeding.How can I get more information about Kineret?For more information about Kineret, you can visit the manufacturer’s website at www.kineretrx.com or call them at 866-547-0644.
about
Kineret is used to treat certain inflammatory conditions. It works by blocking the effects of a natural substance called interleukin-1, which helps reduce inflammation. Common side effects include injection site reactions, common cold symptoms, and headache. Serious side effects can include severe infections. Tell your health care provider right away if you think you have an infection or develop symptoms such as fever, sweats, chills, or muscle aches.