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Ticlast (Azelastine Hydrochloride and Fluticasone Propionate): Side Effects, Uses, Dosage, Interactions, Warnings

Ticlast

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 1/18/2023

Drug Summary

Last reviewed on RxList 5/10/2018

Dymista (azelastine hydrochloride and fluticasone propionate) is a combination of an antihistamine (H1 receptor antagonist) and a corticosteroid indicated for the relief of symptoms of seasonal allergic rhinitis in patients 12 years of age and older who require treatment with both azelastine hydrochloride and fluticasone propionate for symptomatic relief. Side effects of Dymista include:

  • sleepiness or drowsiness,
  • nasal problems,
  • nosebleed,
  • altered sense of taste,
  • headache,
  • sinus pain,
  • cough,
  • sore throat,
  • slow wound healing,
  • thrush (Candida, a fungal infection in your nose and throat),
  • eye problems such as glaucoma or cataracts, and
  • immune system problems that can increase your risk of infections.

Tell your doctor if you have serious side effects of Dymista including:

  • severe or ongoing nosebleeds;
  • noisy breathing, runny nose, or crusting around your nostrils;
  • redness, sores, or white patches in your mouth or throat;
  • fever, chills, weakness, nausea, vomiting, flu symptoms;
  • wounds that will not heal; or
  • blurred vision, eye pain, or seeing halos around lights.

For intranasal use only, the recommended dose is 1 spray per nostril twice daily in adults and adolescents 12 years of age and older. Dymista may interact with other medicines that make you sleepy (such as cold or allergy medicines, narcotic pain medicines, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety), conivaptan, imatinib, isoniazid, nefazodone, antibiotics, antifungals, heart or blood pressure medications, hepatitis C medications boceprevir or telaprevir, or HIV/AIDS medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Dymista. Dymista should be used during pregnancy only if prescribed. It is unknown if Dymista passes into breast milk. Consult your doctor before breastfeeding.

Our Dymista Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Description for Ticlast

Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray is formulated as a white, uniform metered-spray suspension for intranasal administration. It is a fixed dose combination product containing an antihistamine (H receptor antagonist) and a corticosteroid as active ingredients.

Azelastine hydrochloride active ingredient occurs as a white, odorless, crystalline powder with a bitter taste. It has a molecular weight of 418.37. It is sparingly soluble in water, methanol, and propylene glycol and slightly soluble in ethanol, octanol, and glycerin. It has a melting point of 225°C and the pH of 5.2. Its chemical name is (±)-1-(2H)-phthalazinone,4-[(4-chlorophenyl) methyl]-2-(hexahydro-1- methyl-1H-azepin-4-yl)-, monohydrochloride. Its molecular formula is C22H24ClN3O•HCl with the following chemical structure:

Azelastine hydrochloride - Structural Formula Illustration

Fluticasone propionate active ingredient is a white powder with a melting point of 273°C, a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol. Fluticasone propionate is a synthetic corticosteroid having the chemical name S-(fluoromethyl)-6α,9- difluoro-11β,-17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate, and the following chemical structure:

Fluticasone propionate - Structural Formula Illustration

Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray, 137 mcg / 50 mcg contains 0.1% solution of azelastine hydrochloride and 0.037% suspension of micronized fluticasone propionate in an isotonic aqueous suspension containing glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, phenylethyl alcohol (2.5 mg/g), edetate disodium, benzalkonium chloride (0.1 mg/g), polysorbate 80, and purified water. It has a pH of approximately 6.0.

After priming [see DOSAGE AND ADMINISTRATION], each metered spray delivers a 0.137 mL mean volume of suspension containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base) and 50 mcg of fluticasone propionate. The 23 g bottle provides 120 metered sprays, after priming.

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