Hydrochlorothiazide and Metoprolol

Hydrochlorothiazide and Metoprolol are combination prescription medications used to treat high blood pressure.

• Hydrochlorothiazide and Metoprolol are available under various brand names: Dutoprol, Lopressor HCT

Common side effects of Hydrochlorothiazide and Metoprolol include:

• tired feeling; or
• stuffy nose, sore throat.

Serious side effects of Hydrochlorothiazide and Metoprolol include:

• hives,
• difficult breathing,
• swelling of the face, lips, tongue, or throat
• bronchospasm (wheezing, chest tightness, trouble breathing);
• slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• low potassium--constipation, numbness or tingling, tiredness, muscle weakness, slow heart rate, fainting; or
• low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Rare side effects of Hydrochlorothiazide and Metoprolol include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Tablet (Lopressor HCT)

• 50 mg/25 mg
• 100 mg/25 mg
• 100 mg/50 mg

Tablet (Dutoprol)

• 25 mg/12.5 mg
• 50 mg/12.5 mg
• 100 mg/12.5 mg

Hypertension

Adult and geriatric dosage

• Lopressor HCT: metoprolol tartrate 50-100 mg and hydrochlorothiazide 25-50 mg orally daily in single or divided doses
• Dutoprol: metoprolol succinate 25-100mg and hydrochlorothiazide 12.5 mg orally every day as a single dose

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Hydrochlorothiazide and Metoprolol have severe interactions with no other drugs.
• Hydrochlorothiazide and Metoprolol have serious interactions with at least 45 other drugs.
• Hydrochlorothiazide and Metoprolol have moderate interactions with at least 279 other drugs.
• Hydrochlorothiazide and Metoprolol have minor interactions with at least 175 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Allergic reaction to hydrochlorothiazide or metoprolol
• a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), or if your heart cannot pump blood properly;
• slow heartbeats that have caused you to faint;
• severe or uncontrolled heart failure;
• an allergy to sulfa drugs; or
• if you are unable to urinate.

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Hydrochlorothiazide and Metoprolol?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Hydrochlorothiazide and Metoprolol?”

Cautions

• You should not use Hydrochlorothiazide and Metoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly.
• You should not use this medicine if you are unable to urinate.
• Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose.
• Do not stop using Hydrochlorothiazide and Metoprolol suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose.
• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
• Drinking alcohol can further lower your blood pressure and may increase certain side effects of Hydrochlorothiazide and Metoprolol.
• Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
• Drinking alcohol can further lower your blood pressure and may increase certain side effects of Hydrochlorothiazide and Metoprolol.
• Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Pregnancy & Lactation

• It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
• Lactation
  • Hydrochlorothiazide and Metoprolol can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.