Hydrocortisone-Pramoxine

Hydrocortisone and Pramoxine are combination prescription medications used to treat itching and discomfort caused by allergic reactions, eczema, minor burns, insect bites, or other skin conditions.

• Hydrocortisone and Pramoxine are available under various brand names: Analpram E, Analpram-HC, Enzone, Epifoam, HC Pramoxine, Pramcort, Pramosone, Pramosone E, ProCort, Proctocream HC, Proctofoam HC, Rectocort HC, Zone-A, Zone-A Forte, Z-Pram, ZyPram

Common side effects of Hydrocortisone and Pramoxine include:

• mild redness or swelling of treated skin;
• thinning of treated skin; or
• numbness on areas where the medicine is accidentally applied.

Serious side effects of Hydrocortisone and Pramoxine include:

• hives,
• difficulty breathing,
• swelling of the face, lips, tongue, or throat,
• blurred vision, eye pain, or seeing halos around lights;
• mood changes;
• rectal bleeding;
• severe irritation at the application site;
• sleep problems (insomnia);
• high blood sugar (increased thirst or urination, hunger, dry mouth, fruity breath odor, weight loss);
• weight gain, puffiness in the face; or
• muscle weakness, feeling tired.

Rare side effects of Hydrocortisone and Pramoxine include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Rectal aerosol foam

• 1% HC/1% Pramoxine

Cream

• 0.5% HC/1% Pramoxine
• 1% HC/1% Pramoxine
• 2.5% HC/1% Pramoxine

Lotion

• 1% HC/1% Pramoxine
• 2.5% HC/1% Pramoxine

Topical Inflammation

Adult and geriatric dosage

• Relief of inflammation and pruritus associated with corticosteroid-responsive dermatoses
• Apply to the affected area every 6-8 hours depending on the severity of the condition

Hemorrhoids

• Adult and geriatric dosage
• Apply rectally every 6-8 hours
• Administration: Using a rectal applicator, insert the tip into the anus and expel measured cream/foam

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Hydrocortisone and Pramoxine have no noted severe interactions with any other drugs.
• Hydrocortisone and Pramoxine have no noted serious interactions with any other drugs.
• Hydrocortisone and Pramoxine have no noted moderate interactions with any other drugs.
• Hydrocortisone and Pramoxine have no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Allergic to hydrocortisone or Pramoxine, or any other anesthetics or "numbing medicines.".

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Hydrocortisone and Pramoxine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Hydrocortisone and Pramoxine?”

Cautions

• Hydrocortisone and Pramoxine topical will not treat a bacterial, fungal, or viral skin infection. If you have a skin infection, you should not use this medication until your infection is treated and clears up.
• Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
• Your body may absorb too much of this medication if you use a large amount, if you apply it over large skin areas, or if you cover treated skin with heat, bandages, or plastic wrap. Skin that is cut or irritated may also absorb more topical medication than healthy skin.
• Do not apply this medication to swollen skin areas or deep puncture wounds. Avoid using the medicine on skin that is raw or blistered, such as a severe burn or abrasion. Avoid using on body areas where you have skin folds or thin skin unless your doctor has told you to.
• Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If this does happen, rinse with water.

Pregnancy & Lactation

• It is not known whether hydrocortisone and Pramoxine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
• Lactation
  • It is not known whether hydrocortisone and Pramoxine pass into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.