Motegrity (Prucalopride Tablets): Side Effects, Uses, Dosage, Interactions, Warnings

Drug Summary

What Is Motegrity?

Motegrity (prucalopride) is a serotonin-4 (5-HT4) receptor agonist indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

What Are Side Effects of Motegrity?

Motegrity may cause serious side effects including:

hives,
difficulty breathing,
swelling of your face, lips, tongue, or throat,
unusual changes in mood or behavior,
ongoing or worsening depression,
thoughts of self-harm,
sadness, and
hopelessness

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Motegrity include:

headache,
abdominal pain,
nausea,
diarrhea,
bloating,
dizziness,
vomiting,
gas (flatulence), and
fatigue

Seek medical care or call 911 at once if you have the following serious side effects:

Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Motegrity

The recommended dose of Motegrity is 2 mg once daily.

What Drugs, Substances, or Supplements Interact with Motegrity?

Motegrity may interact with erythromycin or ketoconazole. Tell your doctor all medications and supplements you use.

Motegrity During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Motegrity; it is unknown how it would affect a fetus. Motegrity passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Motegrity (prucalopride) Tablets, for Oral Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Description for Motegrity

MOTEGRITY (prucalopride) tablets for oral use contain prucalopride succinate, a dihydrobenzofurancarboxamide that is a serotonin type 4 (5-HT₄) receptor agonist. The IUPAC name is: 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydrobenzofuran-7-carboxamide succinate.

The molecular formula is C₁₈H₂₆ClN₃O₃.C₄H₆O₄ and the molecular weight is 485.96. The structural formula is:

MOTEGRITY (prucalopride) Structural Formula Illustration

Prucalopride succinate is a white to almost white powder. It is highly soluble in acidic aqueous media and alkaline aqueous media up to a pH of approximately 9.

Each 1-mg film-coated tablet of MOTEGRITY contains 1 mg of prucalopride (equivalent to 1.32 mg prucalopride succinate), and the following inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The coating for the 1-mg tablet contains hypromellose, lactose monohydrate, polyethylene glycol 3000, titanium dioxide, and triacetin.

Each 2-mg film-coated tablet of MOTEGRITY contains 2 mg of prucalopride (equivalent to 2.64 mg prucalopride succinate), and the following inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The coating for the 2-mg tablet contains hypromellose, lactose monohydrate, polyethylene glycol 3000, titanium dioxide, triacetin, red iron oxide, yellow iron oxide, and FD&C Blue #2.

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