Neomycin

Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic)  are combination prescription medications used to treat eye inflammation caused by uveitis, eye injury, radiation, chemical burns, or certain other conditions. 

• Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic)  are available under various brand names: AK-Trol, Dexacidin, Dexacine, Dexasporin, Maxitrol, Methadex, Ocu-Trol, Poly-Dex

Common side effects of Dexamethasone, Neomycin and Polymyxin B (Ophthalmic)  include:

• blurred vision; or
• mild eye irritation.

Serious side effects of Dexamethasone, Neomycin and Polymyxin B (Ophthalmic)  include:

• hives,
• difficult breathing,
• swelling of the face, lips, tongue, or throat,
• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);
• pain behind your eyes, sudden vision changes; or
• a wound that will not heal.

Rare side effects of Dexamethasone, Neomycin and Polymyxin B (Ophthalmic)  include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Ophthalmic ointment

• (0.1%/3.5 mg/10,000 units)/g (3.5 g)
• Ophthalmic suspension
• (0.1%/3.5 mg/10,000 units)/mL (5 mL)
• Inflammatory Ocular Conditions/Infections

Adult and pediatric dosage

• Ophthalmic suspension: Instill 1-2 drops to the affected eye(s) every 4-6 hours; may use hourly in severe disease followed by a taper for discontinuation
• Ophthalmic ointment: Apply ribbon (~0.5-in) to the affected eye(s) in the conjunctival sac every 4-6 hours or as an adjunct to suspension.

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic)  have severe interactions with the following drugs:
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • apixaban
• Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic)  have serious interactions with at least 131 other drugs.
• Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic)  have moderate interactions with at least 316 other drugs.
• Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic)  have minor interactions with at least 125 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to dexamethasone, neomycin, or polymyxin B
• Fungal or viral infection in your eyes (including herpes simplex).

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic) ?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Dexamethasone, Neomycin, and Polymyxin B (Ophthalmic) ?”

Cautions

• You should not use this medicine if you have a fungal or viral infection in your eyes (including herpes simplex).
• Do not give this medicine to a child without medical advice.
• If you use this medicine for longer than 10 days, you may need frequent vision tests to check the pressure inside your eyes.
• Do not share this medicine with another person, even if they have the same symptoms you have.
• This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Pregnancy and Lactation

• It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Lactation

• It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.