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Selseb (Selenium Sulfide 2.25%): Side Effects, Uses, Dosage, Interactions, Warnings

Selseb

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 8/16/2022

Drug Summary

What Is Selseb?

Selseb (selenium sulfide 2.25%) shampoo is a liquid antiseborrheic, antifungal preparation for the treatment of seborrheic dermatitis of the scalp, dandruff, and tinea versicolor. Selseb is available in the generic form termed selenium sulfide.

What Are Side Effects of Selseb?

Side effects of Selseb include:

  • skin irritation
  • an increase in normal hair loss
  • discoloration of the hair
  • oiliness, and
  • dryness of the hair and scalp

Serious side effects of Selseb include allergic reactions and eye and skin irritation.

Selseb may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • rash,
  • itching,
  • severe dizziness, and
  • trouble breathing

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Selseb

Each gram of Selseb Shampoo contains 22.5 mg selenium sulfide in a viscous suspension of 180 ml. Dosage for Selseb depends on the condition for which the shampoo was prescribed. For seborrheic dermatitis and dandruff: Generally 2 applications each week for 2 weeks will control symptoms. Subsequently, shampoo may be used less frequently - weekly, every 2 weeks, every 3 to 4 weeks or as directed by a physician. Selseb should not be applied more frequently than necessary to maintain control. For tinea versicolor: Apply to affected areas and lather with a small amount of water. Allow product to remain on skin for 10 minutes, then rinse thoroughly. Repeat procedure once a day for seven days or as directed by a physician.

What Drugs, Substances, or Supplements Interact with Selseb?

Selseb may interact with other topical medications. Tell your doctor all medications and supplements you use.

Selseb During Pregnancy or Breastfeeding

It is also not known whether Selseb can cause fetal harm when applied to the body surfaces of a pregnant woman or can affect reproduction capacity. Under ordinary circumstances, Selseb should not be used by pregnant women. It is not known whether or not selenium sulfide is secreted in human milk. Because many drugs are secreted in human milk, caution should be exercised when Selseb is administered to a nursing woman. Safety and effectiveness in the pediatric has not been established for Selseb.

Additional Information

Our Selseb Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Description for Selseb

A liquid antiseborrheic, antifungal preparation for topical application.

Each gram of Selseb Shampoo contains 22.5 mg selenium sulfide, urea, zinc pyrithione, purified water, edetate disodium, prppylene glycol, diazolidinyl urea, methylparaben, propylparaben, hypromellose, ammonium lauryl sulfate, titanium dioxide, caprylic/capric trigiyceride, D&C yellow #8, FD&C red #40, chromium oxide greens, citric acid, sodium citrate, cocamidopropyl betaine, lauramide DEA, magnesium aluminum silicate and fragrance.

Uses for Selseb

A liquid antiseborrheic, antifungal preparation for the treatment of seborrheic dermatitis of the scalp, dandruff and tinea versicolor. Urea hydrates and is useful for conditions such as dry scalp.

Dosage for Selseb

For seborrheic dermatitis and dandruff: Generally 2 applications each week for 2 weeks will control symptoms. Subsequently, shampoo may be used less frequently - weekly, every 2 weeks, every 3 to 4 weeks or as directed by a physician. Should not be applied more frequently than necessary to maintain control.

For tinea versicolor: Apply to affected areas and lather with a small amount of water. Allow product to remain on skin for 10 minutes, then rinse thoroughly. Repeat procedure once a day for seven days or as directed by a physician.

HOW SUPPLIED

Selseb (selenium sulfide 2.25%) Shampoo is supplied in 180 ml bottles, NDC 10337-500-10.

Store at controlled room temperature 15°- 30° C (59°- 86° F). Protect from freezing.

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Mfd.for: DERM/arts® Division Doak Dermatologics A Subsidiary Of Bradley Pharmaceuticals, Inc. 383 Route 46 West • Fairfield, New Jersey 07004-2402.
www.doakderm.com. Manufactured by: Groupe Parima, Inc., Montreal, QC H4S 1X6 CANADA. Rev. 11/05

Side Effects for Selseb

In decreasing order of severity: skin irritation; occasional reports of increase in normal hair loss; discoloration of hair (can be avoided or minimized by thorough rinsing of hair after treatment). As with other shampoos, oiliness or dryness of hair and scalp may occur.

Drug Interactions for Selseb

No information provided.

Warnings for Selseb

For external use only. Not for ophthalmic use. DO NOT USE ON BROKEN SKIN OR INFLAMED AREAS. If allergic reaction occurs, discontinue use. Avoid contact with eyes, genital areas and skin folds, as irritation and burning may result. If accidental contact occurs, rinse thoroughly with water.

Precautions for Selseb

This medication is to be used as directed by a physician. Not to be used when inflammation or exudation is present as increased absorption may occur.

Carcinogenesis

Dermal application of 25% and 50% solutions of 2.5% selenium sulfide lotion on mice over an 88-week period indicated no carcinogenic effects.

Use In Pregnancy

Category C. Animal reproduction studies have not been conducted with Selseb. It is also not known whether Selseb can cause fetal harm when applied to the body surfaces of a pregnant woman or can affect reproduction capacity. Under ordinary circumstances, Selseb should not be used by pregnant women.

Nursing Mothers

It is not known whether or not this drug is secreted in human milk. Because many drugs are secreted in human milk, caution should be exercised when Selseb is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in children have not been established.

Overdose Information for Selseb

There are no documented reports of serious toxicity in humans resulting from acute ingestion of Selseb. However, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity. Evacuation of the stomach contents should be considered in cases of acute oral ingestion.

Contraindications for Selseb

Contraindicated in persons with known or suspected hypersensitivity to any of the listed ingredients.

Clinical Pharmacology for Selseb

Selenium sulfide appears to have a cytostatic effect on cells of the epidermis and follicular epithelium, reducing corneocyte production.

Pharmacokinetics

The mechanism of action of topically applied selenium sulfide is not yet known.

Patient Information for Selseb

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

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