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Yocon (Yohimbine Hydrochloride): Side Effects, Uses, Dosage, Interactions, Warnings

Yocon

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 12/15/2021

Drug Summary

What Is Yocon?

Yocon (yohimbine hydrochloride) increases the amount of blood that flows into the penis and prevents blood from flowing out of the penis, used to treat and diagnose some types of impotence. Yocon can cause an erection.

What Are Side Effects of Yocon?

Common side effects of Yocon include:

  • dizziness,
  • headache,
  • nausea,
  • flushing,
  • anxiety,
  • irritability,
  • nervousness, or
  • tremor (shaking)
    • T

Tell your doctor is you experience serious side effects of Yocon such as an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives), a very irregular or fast heartbeat, confusion, or unusual behavior.

Dosage for Yocon

The dosage of Yocon to treat erectile impotence in adult males is 1 tablet (5.4 mg), taken orally, 3 times a day.

What Drugs, Substances, or Supplements Interact with Yocon?

Yocon may interact with medicine for depression, mania, or another psychiatric condition. Tell your doctor all medications you use. Yocon is not usually used in women.

Yocon During Pregnancy or Breastfeeding

Therefore, it is unlikely to be used during pregnancy or breastfeeding. Consult your doctor if you have any questions about this medication.

Additional Information

Our Yocon (yohimbine hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Description for Yocon

Yohimbine is a 3alpha -15alpha -20beta -17alpha -hydroxy Yohimbine-16alpha - carboxylic acid methyl ester. The alkaloid is found in Rubaceae and related trees. Also in Rauwolfia Serpentina (L) Benth. Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. It is a crystalline powder, odorless. Each compressed tablet contains (1/12 gr.) 5.4 mg of Yohimbine Hydrochloride.

Uses for Yocon

Yocon (yohimbine hydrochloride) is indicated as a sympathicolytic and mydriatic. It may have activity as an aphrodisiac.

Dosage for Yocon

Experimental dosage reported in treatment of erectile impotence:1, 3, 4 1 tablet (5.4 mg) 3 times a day, to adult males taken orally. Occasional side effects reported with this dosage are nausea, dizziness or nervousness. In the event of side effects dosage is to be reduced to ½ tablet 3 times a day, followed by gradual increases to 1 tablet 3 times a day. Reported therapy not more than 10 weeks.3

HOW SUPPLIED

Yocon ® (Yohimbine Hydrochloride, USP) Tablets 1/12 gr 5.4 mg Bottles of 100 - NDC 0516-0001-01 Bottles of 1,000 - NDC 0516-0001-10

 1. A. Morales et al., New England Journal of Medicine: 1221. November 12, 1981.

 3. Weekly Urological Clinical letter, 27:2, July 4, 1983

 4. A. Morales et al., The Journal of Urology 128: 45-47, 1982.

Glenwood, LLC., 111 Cedar Lane, Englewood, NJ 07631. 1-800-542-0772. Page Last Updated: Tuesday, April 1st: 2008. FDA rev date: n/a

Side Effects for Yocon

Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, irritability, and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug.1,2 Also dizziness, headache, skin flushing reported when used orally.1,3

Drug Interactions for Yocon

No information provided.

 1. A. Morales et al., New England Journal of Medicine: 1221. November 12, 1981.

 2. Goodman, Gilman - The Pharmacological basis of Therapeutics 6th ed., p. 176- 188, McMillan

 3. Weekly Urological Clinical letter, 27:2, July 4, 1983

Warnings for Yocon

Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor, should it be used in conjunction with mood-modifying drugs such as antidepressants, or in psychiatric patients in general.

Precautions for Yocon

No information provided.

Overdose Information for Yocon

No information provided.

Contraindications for Yocon

Renal diseases, and patients sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.

Clinical Pharmacology for Yocon

Action

Yocon (yohimbine hydrochloride) blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of shorter duration. Yohimbine's peripheral autonomic nervous system effect is to increase parasympathetic (cholinergic) and decrease sympathetic (adrenergic) activity. It is to be noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may theoretically result in increased penile inflow, decreased penile outflow or both.

Yohimbine exerts a stimulating action on the mood and may increase anxiety. Such actions have not been adequately studied or related to dosage although they appear to require high doses of the drug. Yohimbine has a mild anti-diuretic action, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone.

Reportedly, Yohimbine exerts no significant influence on cardiac stimulation and other effects mediated by beta-adrenergic receptors. Its effect on blood pressure, if any, would be to lower it; however, no adequate studies are at hand to quantitate this effect in terms of Yohimbine dosage.

Patient Information for Yocon

No information provided. Please refer to the WARNINGS section.

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