Mometasone Intranasal

Mometasone intranasal is a prescription medication used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by allergic rhinitis, seasonal allergic rhinitis, and nasal polyps.

• Mometasone intranasal is available under the following different brand names: Nasonex

Adult and pediatric dosage

Nasal spray suspension

• 50mcg/spray

Allergic Rhinitis

Adult dosage

• 2 sprays (100 mcg) in each nostril once daily

Pediatric dosage

• Children below 2 years: Safety and efficacy not established
• Children between 2 to 12 years: 1 spray (50 mcg) in each nostril once daily
• Children above 12 years: 2 sprays (100 mcg) in each nostril once daily

Seasonal Allergic Rhinitis

Adult dosage

• Treatment: 2 sprays (100 mcg) in each nostril once daily
• Prophylaxis: 2 sprays (100 mcg) in each nostril once daily; initiate 2-4 weeks before pollen season

Pediatric dosage

Treatment

• Children below 2 years: Safety and efficacy not established
• Children 2 to 12 years: 1 spray (50 mcg) in each nostril once daily
• Children above 12 years: 2 sprays (100 mcg) in each nostril once daily

Prophylaxis

• Children below 12 years: Safety and efficacy not established
• Children above 12 years: 2 sprays (100 mcg) in each nostril once daily; initiate 2-4 weeks before allergy season

Nasal Polyps

Adult dosage

• 2 sprays (100 mcg) in each nostril every 12 hours; once daily dosing may be effective in some patients

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

Common side effects of Mometasone Intranasal include:

• headache,
• stuffy nose,
• sore throat,
• cough,
• muscle or joint pain,
• nausea,
• nose/throat dryness or irritation,
• blood-tinged mucus/phlegm, and
• sores or white patches inside or around the nose.

Serious side effects of Mometasone Intranasal include:

• epistaxis,
• ulcerations,
• glaucoma,
• cataracts,
• nasal candidiasis,
• nasal septal perforation,
• hypersensitivity reactions-wheezing, and
• angioedema

Rare side effects of Mometasone Intranasal include:

• none 

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Mometasone Intranasal has severe interactions with the following drug:
  • desmopressin
• Mometasone Intranasal has serious interactions with no other drugs.
• Mometasone Intranasal has moderate interactions with the following drugs:
  • atazanavir
  • ceritinib
  • clarithromycin
  • cobicistat
  • darunavir
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • idelalisib
  • indinavir
  • itraconazole
  • ketoconazole
  • levoketoconazole
  • lopinavir
  • mifepristone
  • nefazodone
  • nelfinavir
  • ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC)
  • posaconazole
  • ritonavir
  • saquinavir
  • voriconazole
• Mometasone Intranasal has minor interactions with no other drugs. 

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns.

Contraindications

• Hypersensitivity
• Recent nasal surgery, nasal trauma, nasal septum ulcers (until healing has occurred)

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Mometasone Intranasal?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Mometasone Intranasal?”

Cautions

• Monitor for vision change or, with history of increased IOP, glaucoma, or for cataracts; glaucoma and cataracts reported with systemic and topical (including nasal, inhaled, and ophthalmic) corticosteroid use; consider referral to an ophthalmologist in patients who develop ocular symptoms or receive therapy long term
• Respiratory tract fungal or bacterial infections, viral/parasitic infections, or ocular herpes simplex may occur
• Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex
• Epistaxis observed more frequently in patients with allergic rhinitis with the drug than those who received placebo
• In clinical studies, the development of localized infections of the nose and pharynx with Candida albicans reported; when infection develops, use should be discontinued and appropriate local or systemic therapy instituted if needed
• Instances of nasal septum perforation reported following nasal application of corticosteroids; as with any long-term topical treatment of a nasal cavity, patients receiving therapy over several months or longer should be examined periodically for possible changes in the nasal mucosa
• Because of the inhibitory effect of corticosteroids on wound healing, patients who have experienced recent nasal septum ulcers, nasal surgery, or nasal trauma should not use a nasal corticosteroid until healing has occurred
• Hypersensitivity reactions including instances of wheezing may occur after nasal administration of mometasone furoate monohydrate; discontinue therapy if such reactions occur
• When nasal steroids are used at higher than recommended dosages or in susceptible individuals at recommended dosages, systemic corticosteroid effects such as hypercorticism and adrenal suppression may appear; if this occurs, slowly discontinue dosage of the drug, consistent with accepted procedures for discontinuing oral corticosteroid therapy
• Corticosteroids may cause a reduction in growth velocity when administered to pediatric patients; monitor growth routinely of pediatric patients receiving therapy to minimize systemic effects of therapy, titrate each patient’s dose to the lowest dosage that effectively controls his/her symptoms
• Immunosuppression and risk of infections
  • Persons who are on drugs that suppress the immune system are susceptible to infections; chickenpox and measles, for example, can have a more serious or even fatal course in nonimmune children or adults on corticosteroids
  • Children or adults who have not had these diseases, should take care to avoid exposure; how dose, route, and duration of corticosteroid administration affect the risk of developing a disseminated infection not known
  • If exposed to chickenpox, prophylaxis with varicella-zoster immune globulin (VZIG) may be indicated; if exposed to measles, prophylaxis with pooled intramuscular immunoglobulin (IG) may be indicated; if chickenpox develops, treatment with antiviral agents may be considered
  • Corticosteroids should be used with caution, if at all, in patients with active or quiescent tuberculous infection of the respiratory tract, or untreated fungal, bacterial, systemic viral infections, or ocular herpes simplex because of the potential for worsening of these infections

Pregnancy and Lactation

• There are no adequate and well-controlled clinical studies in pregnant women
• Lactation
  • There are no available data on the presence of drugs in human milk, effects on the breastfed child, or milk production; other corticosteroids are excreted in human milk
  • The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed infant from the drug or underlying maternal condition