Propylhexedrine

Propylhexedrine is an over-the-counter (OTC) medication used for the treatment of Nasal Congestion.

• Propylhexedrine is available under the following different brand names: Benzedrex.

Common side effects of Propylhexedrine include:

• Rapid heart rate, 
• Agitation, 
• High blood pressure, 
• Chest pain, tremors,
• Hallucinations, 
• Delusions, 
• Confusion,
• Nausea, and vomiting.

Serious side effects of Propylhexedrine include:

• Severe anxiety or agitation, 
• confusion, 
• hallucinations,
• paranoia. 
• Rapid heartbeat or abnormal heart rhythm. 
• Chest pain or tightness.

Rare side effects of Propylhexedrine include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out. 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Intranasal inhaler

• 250 mg/actuation

Nasal Congestion

Adult dosage

• 1-2 inhalations per nostril every 2 hours or as needed; not to exceed 3 days.

Pediatric dosage

• Below 6 years: Not recommended.
• Above 6 years: 1-2 inhalations per nostril every 2 hours as needed; not to exceed 3 days.

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Propylhexedrine has severe interactions with the following drugs:
• isocarboxazid
  • linezolid
  • phenelzine
  • selegiline transdermal
  • tranylcypromine
• Propylhexedrine has serious interactions with the following drugs:
  • amitriptyline
  • amoxapine
  • cabergoline
  • clomipramine
  • desflurane
  • desipramine
  • dihydroergotamine
  • dihydroergotamine intranasal
  • doxapram
  • doxepin
  • ergoloid mesylates
  • ergotamine
  • ether
  • imipramine
  • isoflurane
  • lofepramine
  • maprotiline
  • methoxyflurane
  • methylergonovine
  • nortriptyline
  • protriptyline
  • trazodone
  • trimipramine
  • yohimbe
• Propylhexedrine has moderate interactions with at least 167 other drugs.
• Propylhexedrine has minor interactions with the following drugs:
  • desmopressin
  • eucalyptus
  • sage

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice or health questions or concerns.

Contraindications

• Hypersensitivity to drugs or components

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Propylhexedrine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Propylhexedrine?”

Cautions

• Do not exceed recommended dosage.
• This product may cause temporary discomfort such as burning, stinging, sneezing, or an increase in nasal discharge.
• The use of this container by more than one person may spread infection.
• Use only as directed.
• Frequent or prolonged use may cause nasal congestion to recur or worsen.
• Ill effects may result if taken internally.

Pregnancy and Lactation

• Ask a healthcare professional.
• Lactation
  • Ask a healthcare professional.